Description
We are seeking a Research Associate II to help grow the Process Development team within Genomics Early Development. The ideal candidate will work to optimize next-generation sequencing (NGS) processes and develop new methodologies on our multiomics platform.
This person will work cross-functionally with Research & Development, Automation, Computation Science, Quality, Regulatory, Laboratory Operations, and Program Management on the development, characterization, scale-up and transfer of complex methodologies, processes and assays to Operations.
You will apply hands-on knowledge of molecular biology, nucleic-acid biochemistry and next generation sequencing to develop and optimize NGS based methods and processes.
Key responsibilities include:
- Execute experiments to characterize and optimize NGS workflows, converting prototypes into high-throughput automated assays.
- Participate in data analysis and visualizations to answer experimental questions and identify areas for workflow optimization.
- Present findings at team meetings and prepare technical reports for internal and external stakeholders.
- Collaborate with cross-functional teams to integrate process improvements into the overall diagnostic workflow.
- Assist with generating Standard Operating Procedures and Work Instructions with Laboratory Operations and Clinical Laboratory for transfer.
- Support troubleshooting workflow issues, perform root-cause determinant experiments and propose effective data-driven solutions.
- Maintain detailed records of experiments, data, results and methodologies in compliance with Good Laboratory and Documentation Practices (cGLP, cGDP).
Requirements include:
- Bachelor’s or Master’s in Molecular Biology, Genetics, Biochemistry, or a related field with 2+ years of relevant industry experience.
- Hands-on experience in NGS based techniques, including nucleic acid extraction, library preparation, and sequencing.
- Experience with handling plasma and cfDNA in NGS workflows with low-volume, plate-based assay formats.
- Effectively communicates with team and cross-functional partners.
- High attention to detail - record and document accurate, objective observations, assess impact, and perform troubleshooting as needed.
- Excellent problem-solving skills, proactively looks for potential roadblocks, characterizes root causes to problems and collaborates with appropriate stakeholders.
- Ability to work independently as well as part of a cross-functional team.
- Flexible and adaptable to change and embrace a fluid work environment.
Nice to have:
- Familiarity in a common scientific programming language (e.g., Python, R)