Principal Scientist - In Vivo Expert, CVRI (Cardiovascular, Renal & Immunology)

At Bayer, we're seeking a highly motivated Principal Scientist to join our Cardiovascular-Renal In Vitro Research group based at the Bayer Innovation Campus in Cambridge, MA. As a Principal Scientist, you will be responsible for enhancing internal expertise in the heart and kidney in vivo biology space. You will design and conduct experimental research studies, coach research associates, and propose therapeutics project(s) targeting cardiac or renal (including cardio-renal metabolic) disease.

Your primary responsibilities will include:

• Identifying and setting up relevant mechanistic and disease in vivo models to support cardiovascular and renal projects from target identification to preclinical candidate acceptance and early clinical development.
• Preparing and updating experimental protocols.
• Independently performing data analysis and effectively interpreting results.
• Supporting evaluation of external innovation landscape in the field of in vivo models and connection to external partners (CROs, academic partners).
• Leading novel target proposals and experimental validation to support growth of our early cardiovascular & renal portfolio.
• Supporting BD&L assessment of external targets and programs to understand the competitive landscape and identify potential opportunities for collaboration or technological innovation.
• Engaging in close collaboration with scientists and technical staff of the In Vivo Cluster based at the German sites to share knowledge, drive progress and stimulate innovation.
• Leading publication of results, preparing reports and presentations at both internal and external forums.
• Coaching research associates in a matrix organization.
• Collaborating effectively with colleagues and interdisciplinary teams both within Bayer and with external collaborators.
• Ensuring that all tasks are aligned with respect to HSE guidelines, animal welfare law and regulations, documentation guidelines, and good research practices.

We seek an incumbent who possesses the following qualifications:

• A Ph.D. in Biology (Cellular, Molecular or Developmental Biology), Biochemistry, or related life science field.
• A background in cardiorenal disease biology would be highly advantageous.
• In-depth expertise and hands-on experience in mechanistic and disease renal and cardiac in vivo models and its translation to cardiovascular or renal disease modeling and drug discovery.
• Hands-on experience in setting up and characterizing in vivo renal and cardiac rodent models for disease modeling and profiling of drug candidates.
• Strong expertise in clinically relevant readouts (including imaging, hemodynamics, and biomarker) to characterize in vivo models.
• Track record of working on complex problems, and ability to integrate data from multiple disciplines.
• Strong interpersonal, influencing, and collaboration skills to work in a team-oriented, matrix environment, and the ability to work through conflicts.
• Must demonstrate outstanding personal initiative, and accountability, communication skills, and the ability to work effectively as part of a team.
• Ability to adapt, prioritize activities to and effectively manage changes in a fast-paced and dynamic environment.
• A passion for science and sense of urgency to find new medicines to benefit patients.

Preferred qualifications include 8+ years of relevant post-PhD experience including 4+ years in industry with a proven record of successful team leadership and interaction with collaborators.