Description
We are seeking a highly motivated Research Associate with broad expertise conducting in vivo studies, histology preparation and analysis, and molecular biology.
This individual will play an important role in generating high-quality data on the biodistribution, target engagement, and biological response of our molecules in animal models.
Key Responsibilities:
- In Vivo Pharmacology:
- Conduct in vivo studies in rodent models including experience with peripheral administration (IV, IP, SC) and stereotactic surgeries for direct to CNS administration.
- Conduct terminal procedures, including animal takedowns, blood collection, and necropsies.
- Perform tissue harvesting and dissection as appropriate for downstream bioanalytical and histological applications.
- Histology & Imaging:
- Prepare, embed, and section a variety of mammalian tissues using microtome, vibratome, or cryostat techniques (FFPE or fresh-frozen samples).
- Perform immunohistochemistry (IHC) and immunofluorescence (IF) on tissue sections.
- Acquire high-quality images using epifluorescence and/or confocal microscopy.
- Perform in vivo and ex vivo fluorescence and bioluminescence imaging using IVIS or equivalent small-animal imaging systems, including organ collection, image acquisition, and quantitative analysis of signal intensity and tissue distribution.
- Conduct quantitative image analysis (cell counts, regional MFI, colocalization analysis, morphometric quantification) using software such as ImageJ, QuPath, Halo, or equivalent platforms.
- Molecular Biology:
- Perform measurement of gene and protein expression analyses using qRT-PCR, Western blotting, and ELISA methodologies and interpret data.
- Report results clearly to the scientific team.
Qualifications and Skills:
- Bachelor’s degree or higher in Cell Biology or a related field, with 1+ years of laboratory experience, preferably in the biopharmaceutical industry.
- Strong hands-on experience with rodent in vivo studies.
- Strong hands-on experience in histology, including tissue embedding, sectioning, staining, IHC/IF, and imaging.
Additional Qualifications (preferred but not required):
- Authorship on a peer reviewed publication.
- Experience with multiplex IHC/IF and advanced image analysis platforms.
Benefits:
- Healthcare coverage.
- Annual incentive program.
- Retirement benefits.
- A broad range of other benefits.