Description
We are seeking a motivated, highly collaborative, and technically versatile Principal Scientist to help build FL132’s amyloid research platform from the ground up. This is a hands-on role at the interface of protein biophysics, chemical biology, structural biology, and neurodegeneration.
Key Responsibilities:
- Contribute to scientific and technical direction in collaboration with FSP leadership to shape company strategy.
- Establish in-house production and quality control of assay-grade recombinant amyloid proteins.
- Design and analyze amyloid aggregation experiments.
- Characterize amyloid aggregates via mass spectrometry, NMR, AFM, or related methods.
- Support the build of cell-based assays for evaluating amyloid toxicity, seeding, and clearance.
- Evaluate inhibitors of amyloid aggregation and translate findings from biochemical systems into cellular models.
- Scope, contract, and manage CROs and academic collaborations.
- Drive key project goals, ensure rapid, accurate turnaround of data and translate experimental results into insights.
Required Qualifications:
- Ph.D. in structural biology, chemical biology, biochemistry, biophysics, physical chemistry, or a related field, with 8+ years of relevant industry or postdoctoral experience.
- Hands-on recombinant protein expression, purification, and QC.
- Deep expertise with kinetic assays of protein aggregation.
- Familiarity with amyloid aggregation mechanisms and strain/seeding biology.
- Motivated team-player and effective independent contributor with strong organizational and written/verbal communication skills.
Preferred Qualifications:
- Experience with structural characterization of proteins and aggregates using mass spectrometry-based approaches.
- Familiarity with cryo-EM, atomic force microscopy (AFM) or NMR.
- Experience with statistical design of experiments (DoE) and the analysis of large, time-resolved kinetic datasets.
- Experience managing contract research organizations (CROs).
- Familiarity with cell-based neurodegeneration assays.
What we can offer you:
- Opportunity to lay the scientific foundation of a transformative platform company as an early employee.
- Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests.
- Monthly social events, and community lunchroom with free snacks, coffee.