Description
At Pfizer, our purpose is to deliver breakthroughs that change patients' lives. Central to this mission is our Research and Development team, which strives to translate advanced science and cutting-edge technologies into impactful therapies and vaccines.
We are seeking a highly motivated chemical engineer for the role of Senior Scientist-Chemical Engineer to join our API Process Development team within Chemical Research and Development (CRD) in Groton, CT. You will join a diverse team responsible for developing Active Pharmaceutical Ingredients (API) processes for use at manufacturing plants across Pfizer’s network.
Responsibilities
- Apply chemical engineering principles to design and perform laboratory experiments to develop and optimize API manufacturing unit operations.
- Assess scalability and robustness for API processes with understanding of large-scale pharmaceutical manufacturing equipment, capabilities, and operations.
- Evaluate, develop, and apply new process technologies (batch, semi-batch, and continuous flow) to deliver safe, efficient, and sustainable API processes.
- Lead technology transfer of processes to internal clinical and commercial API manufacturing sites and external partners.
- Apply process simulation and statistical tools to characterize the kinetic, thermodynamic, and transport phenomena impacting various unit operations.
- Prepare internal research reports and technical presentations summarizing API process development activities.
- Champion the development of new technology and digital tools to expedite new and existing workflows and capabilities.
- Remain current with the process engineering and chemistry literature.
- Contribute to the preparation of the Chemistry and Manufacturing Controls (CMC) section of the New Drug Application (NDA).
Requirements
- BS with at least 9 years of experience or MS with at least 7 years of experience or PhD with 0+ years of experience in Chemical Engineering.
- Expertise in reaction engineering, including experience developing and validating kinetic models from experimental data.
- Excellent knowledge of chemistry and chemical engineering principles.
- Outstanding laboratory skills, attention to detail, and ability to solve technical problems.
- Exceptional interpersonal, multi-disciplinary team collaboration, and communication skills.
Preferred Requirements
- Working knowledge of reaction modeling, property prediction, and process simulation tools.
- Experience designing, developing, and scaling continuous processes (flow chemistry).
- A good foundational understanding of organic chemistry.
- Working knowledge of crystallization development.
- Working knowledge of Design of Experiment (DOE) studies and statistical analysis.
- Working knowledge of analytical techniques.
- Computational fluid dynamics (CFD) expertise.
- Programing experience, including Python and/or Matlab.
- Applied data science methods.
- Experience in automating laboratory equipment and processes.
Benefits
- Comprehensive and generous benefits and programs to help our colleagues lead healthy lives.
- 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution.
- Paid vacation, holiday and personal days.
- Paid caregiver/parental and medical leave.
- Health benefits to include medical, prescription drug, dental and vision coverage.