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From the employer's careers site First seen 6 Nov 2026

Senior Staff Software Engineer

Freenome Remote senior full-time

Salary

$188,275 - $270,375 per year

Apply on Freenome

Description

We are seeking a Senior Staff Software Engineer to join our Platform team at Freenome. As a Senior Staff Software Engineer, you will shape the technical direction of our platform, mentor other engineers, and stay hands-on with design, code, and operations. Our Platform Engineering team's goal is to multiply the productivity of domain experts by building shared cloud services, including a governed data lakehouse, batch and distributed compute, and self-service environments for research and analytics.

Responsibilities:

  • Shape Platform's technical vision and roadmap, working with engineering and R&D leaders to align platform priorities with company goals.
  • Treat Platform and Data as Products, building trust with leads and SMEs from domain teams, and translating shared needs into reusable platform solutions.
  • Design and ship scalable platform systems, evolving the architecture through reviews, rapid prototypes, and pragmatic technology choices.
  • Drive business-critical initiatives, resolving tradeoffs, sequencing work into incremental deliverables, and delegating to scale execution.
  • Support platform users to unblock critical work, troubleshoot complex system issues, and turn recurring issues into lasting reliability and capacity improvements.
  • Champion AI adoption across Freenome, pairing with domain experts and tailoring guidance and tools to varied technical backgrounds.
  • Expand our team's impact by using AI for platform enhancements, and by building platforms for AI that empower Freenome users to create and deploy secure, cost-effective agentic workflows and LLM-powered applications.
  • Increase visibility of cloud costs, recommend and drive initiatives to reduce waste while protecting performance, reliability, and scientific productivity.
  • Grow other engineers through pairing, design review, delegation, and feedback, while modeling Freenome's values and reinforcing a high-performing culture.

Requirements:

  • 12+ years of relevant software engineering experience or equivalent, preferably in platform teams, delivering complex systems from design to production.
  • 3+ years guiding complex initiatives end-to-end across teams: aligning stakeholders, communicating tradeoffs clearly, and enabling delivery without formal authority.
  • 3+ years building and operating production platforms using Infrastructure as Code on a public cloud, preferably Azure or GCP.
  • Proficiency in Python and at least one other high-level programming language.
  • Deep knowledge of Linux internals, networking, and virtualization, with hands-on troubleshooting and performance tuning at system level.
  • Solid Kubernetes expertise, with experience owning one or more advanced capabilities such as controllers, operators, and CRDs, admission control, scheduling, autoscaling, service mesh, or multi-cluster networking.
  • Sound judgment in distributed systems and platform design, including governance, capacity, reliability, cost, data processing, and storage.
  • Software architecture leadership: you ship clean code, write clear design docs and ADRs, and guide constructive reviews and collaborative technical decisions.
  • You are a force multiplier who enjoys helping engineers or domain experts grow, with a track record of making teams more capable and independent.
  • Success partnering with one or more specialist teams, such as data science, AI/ML, computational biology, or related fields, to improve their workflows.
  • Hands-on AI-assisted development and a record of building reusable tools or workflow automation.

Nice to haves:

  • Experience, familiarity, or a genuine interest in life-sciences software, NGS pipelines, and biological data.
  • ML Ops, model development, and deep learning.
  • Scientific Python frameworks and data-science technology stack.
  • Workflow orchestration and distributed compute frameworks on Kubernetes.
  • Cloud migrations, multi-cloud, or multi-region operations.
  • Columnar processing, open lakehouse technologies, and modern table formats such as Apache Iceberg.
  • FinOps practices, workload cost attribution, and measurable cloud savings.

Benefits:

  • The US target range of our base salary for new hires is $188,275 - $270,375.
  • You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.

Skills

Nice to have

  • Life-sciences software
  • NGS pipelines
  • Biological data
  • ML Ops
  • Deep learning
  • Scientific Python frameworks
  • Workflow orchestration
  • Cloud migrations
  • FinOps practices

Ready to apply?

You apply with the employer directly. Their original posting is here: https://job-boards.greenhouse.io/freenome/jobs/8919668002

Apply on Freenome