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From the employer's careers site First seen 4 Nov 2026

Principal Scientist, Oncology Drug Discovery

GSK Cambridge On-site senior full-time

Salary

$115,500 to $192,500 per year

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Description

We are seeking an experienced Cancer Biologist for an Investigator role to support a growing portfolio of precision oncology assets.

The successful candidate will have a background in cancer biology with experience designing and executing biological studies to understand the mechanism of action small molecule cancer therapeutics.

Responsibilities:

  • Work within a dynamic and global matrix team environment providing basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.
  • Work independently to design, execute, and/or oversee impactful in vitro experiments to inform the development of portfolio assets.
  • Champion innovative experimental techniques or technologies, including medium-throughput scalable assay development, target-specific mechanistic biology, and monotherapy and combination anti-cancer efficacy testing of assets.
  • Build communication networks across the Oncology Research Unit and broader organization.
  • Guide the maturation and de-risking of novel therapeutic concepts.

Basic Qualifications:

  • BS, MS, or PhD in Cell, Molecular, or Cancer Biology, Pharmacology, or a related life sciences field.
  • A minimum of 3 years of experience in designing, executing, and analyzing cellular and molecular biology experiments using small molecular therapeutics and a diverse array of current scientific techniques.

Preferred Qualifications:

  • A minimum of 2 years of drug discovery experience in a biotech, preclinical CRO or pharmaceutical company.
  • Deep knowledge in the field of molecular oncogenesis, signaling pathway, bivalent or molecular glue modality.
  • Deep expertise in assay development in a drug discovery setting.
  • Experience in applying genomic editing techniques to dissect target biology and drug mechanisms.
  • Proven track record of scientific expertise and achievement in cell biology and cancer biology through peer-reviewed publications.
  • Working knowledge of omic methods and databases.

Benefits:

  • Competitive salary
  • Annual bonus based on company performance
  • Healthcare and wellbeing programs
  • Pension plan membership
  • Shares and savings programme
  • Performance with Choice programme offering remote or hybrid working model

Skills

Required

  • Biological Pathways
  • Cancer Research
  • Cross-Functional Teamwork
  • Drug Discovery Process
  • Drug Target Identification
  • Influencing Without Authority
  • Interpersonal Communication
  • Matrix Leadership
  • Proper Documentation
  • Scientific Presentations
  • Scientific Research
  • Scientific Writing

Nice to have

  • Molecular Oncogenesis
  • Signaling Pathway
  • Bivalent or Molecular Glue Modality
  • Assay Development
  • Genomic Editing Techniques
  • Omic Methods
  • Databases
Apply on GSK