Description
We are seeking an experienced bioanalyst for a Senior Technical Specialist - DMPK role at our Cambridge site. As a highly experienced lab and office-based bioanalyst, you will provide wide in-depth scientific and technical expertise to both multidisciplinary integrated Drug Discovery projects and standalone DMPK projects.
This role combines hands-on bioanalytical expertise with project leadership, mentoring, and continuous improvement responsibilities to support small and large molecule drug discovery programmes.
Main Tasks
- Developing, optimising and executing the bioanalysis of samples from in vivo DMPK studies for small and large molecule drug discovery projects in an early discovery setting.
- Extensive knowledge of modern UPLC-MS systems and software including chromatographic method development.
- Demonstrated ability to perform routine and complex troubleshooting, maintenance, and optimisation of mass spectrometry and LC equipment, ensuring reliable operation and rapid resolution of technical issues.
- Experience in the analysis of different sample types such as plasma, blood, brain, lung, bile, faeces, urine.
- Demonstrated experience of pharmacokinetic parameter determination and an understanding of the underlying principles.
- Comprehensive troubleshooting and problem-solving skills using both technical and scientific expertise.
- Strong organisation and time management skills alongside an inbuilt flexibility to adapt to change.
- Excellent communication skills and be an effective team player; these will be essential to successful execution of projects whilst working in a matrix and multi-skilled environment.
- Lead scientific and technical projects, ensuring delivery of high-quality data to agreed timelines.
- Drive innovation through the development of novel assays, protocols and analytical approaches.
- Mentor, coach and develop colleagues, acting as a technical role model and recognised subject matter expert.
Qualifications and Experience
- BSc or equivalent in relevant scientific area.
- Industry experience in pharma, biotech or other commercial organisations.
- Expert user of Mass Spectrometry instrumentation.
- Experience in the bioanalytical method development of challenging analytes, in complex matrices.
- Accurate & diligent experimental planning, execution and troubleshooting.
- Good communication skills (verbal/written) internally and externally.
- Excellent team player.
- Positive ‘can do’ attitude. Creative problem solving.
- Ability to plan & execute work independently.
- Project management.
- Experience of guiding/mentoring junior colleagues.
- LC-MS/MS maintenance and troubleshooting.
- Bespoke method development for small molecules.
What We Offer You We offer a comprehensive benefits package from day one including generous pension, bonus and health cover.