In Vivo Research Associate II, Konermann Lab

Arc Institute is seeking an In Vivo Research Associate II to join the Konermann Laboratory. You will collaborate closely with experienced scientists to advance in vivo projects focused on understanding brain development.

This project builds on previous work in genome-scale CRISPR screening and aims to combine modern functional genomics and neuroscience tools to investigate the molecular mechanisms underlying brain development and function.

The ideal candidate will have experience in animal handling and colony management, intracerebral injections, sample processing for single-cell RNA sequencing and spatial pipelines, and imaging.

Responsibilities:

• Plan, execute, analyze, and troubleshoot experiments with a high degree of independence
• Perform in vivo mouse experiments, including stereotaxic surgeries, as well as IV and IP injections
• Collect and process tissue, including vibratome and/or cryostat sectioning, immunostaining, and imaging
• Comply with federal, Arc, and local IACUC/AAALAC regulations governing animal research
• Analyze and present data at subgroup meetings and seminars
• Maintain an organized, detailed lab notebook

Requirements:

• BS with 2+ years of relevant experience, or MS, in molecular biology, neuroscience, or another relevant field
• Strong experience working with laboratory animals
• Detail-oriented, with excellent organizational and time-management skills
• Outstanding critical thinking and problem-solving skills
• Strong oral and written communication skills
• Highly motivated and curious, with the ability to work effectively both independently and as part of a collaborative team

Preferred Skills:

• Prior experience with cloning via Gibson assembly or Golden Gate protocols
• Knowledge of and experience with NGS library preparation, particularly single-cell and spatial workflows
• Computational skills (Python or R)

The base salary for this position is $75,900.