Description
We are seeking a highly motivated High Content Imaging Scientist to join our Discovery Biology and Pharmacology (DBP) group at the Groton campus in Connecticut.
The successful candidate will have rich experience in high content imaging and high throughput flow cytometry, and apply them to support our diverse small molecule portfolio spanning various therapeutic areas.
Role Responsibilities
- Design, develop, and optimize high-content imaging assays to address project needs
- Independently develop, optimize, and troubleshoot high-content imaging and flow cytometry assays
- Design and implement advanced image-analysis workflows, build complex analysis algorithms, and streamline data processing to support medium- to high-throughput screening
- Translate imaging data into clear, actionable biological insights
- Partner with team experts to support high-content imaging and flow cytometry instrumentation, implement software solutions, and continuously improve imaging infrastructure and workflows
- Execute screening campaigns and mechanism-of-action studies using high-content imaging and/or flow cytometry assays
- Stay current with advances in imaging technologies and partner with the broader team to identify, evaluate, and implement novel imaging technologies and instruments
- Leverage expertise in image algorithm development and imaging hardware and software to support the infrastructure and less experienced assay scientists
Qualifications
- PhD in molecular biology, pharmacology, cell biology, biomedical engineering, or a related discipline (0 to 4 years of work relevant experience), with 2+ years of relevant experience applying fluorescence or confocal microscopy in biological research
- Hands-on experience developing, optimizing, and troubleshooting high-content imaging assays; familiarity with flow cytometry assay platforms is strongly valued
- Strong familiarity with plate-based imaging systems and flow cytometry instrumentation
- Experience using image-analysis software and quantitative data-analysis approaches to extract meaningful biological insights from imaging assay data
- Demonstrated ability to apply imaging-based approaches to address biological questions, troubleshoot technical challenges, and deliver fit-for-purpose assay solutions
- Ability to quickly learn new technologies, adapt them to emerging project needs, and contribute to continuous improvement of imaging capabilities in the group
- Strong verbal and written communication skills, with the ability to work effectively in cross-functional teams and clearly present experimental results and scientific rationale
Nice to Have
- Experience supporting small-molecule discovery programs or pharmacology studies across therapeutic areas such as Internal Medicine, Immunology & Inflammation, or Oncology
- Experience designing and executing cell-based assays to investigate target biology, mechanism of action, or compound activity
- Familiarity with implementing new technologies, instruments, or software tools to improve imaging workflows or expand laboratory capabilities
Benefits
- Comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments
- 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
- Paid vacation, holiday and personal days
- Paid caregiver/parental and medical leave
- Health benefits to include medical, prescription drug, dental and vision coverage