Description
The Director, Oncology Translational Medicine, Clinical Biomarkers is responsible for developing and implementing biomarker and translational medicine strategies to support late-stage oncology assets.
As a key member of a Clinical Matrix Team (CMT), the Clinical Biomarker Director will collaborate with the Clinical Biomarker Executive Director to establish clear decision-making criteria, define patient segmentation strategies, and integrate these into clinical development plans.
Key responsibilities:
- Collaborate with the Clinical Biomarker Executive Director to drive the design, alignment, and execution of clinical biomarker and translational medicine strategies.
- Validate and implement biomarker strategies, including target engagement, pharmacodynamic, and proof-of-mechanism biomarkers.
- Participate in tumor-specific Biomarker Matrix teams and execute clinical biomarker strategies for late-stage oncology programs.
- Represent Translational Medicine at Clinical Development Matrix Teams (CMT) to establish biomarker-driven decision-making criteria.
- Support disease area strategies and translational objectives by defining biomarker priorities and generating decision-enabling evidence packages.
- Identify cutting-edge science and technological advances to incorporate into biomarker strategies.
- Oversee and develop sample testing plans and deliver high-quality biomarker data packages.
- Manage effective relationships with cross-functional teams.
- Support the expansion of mechanism and disease understanding to generate insights for indication expansion.
- Define and study mechanisms of resistance to enable reverse translation and inform next-line strategies.
- Contribute to the company's scientific credibility through publications and presentations.
Basic Qualifications:
- Ph.D. or equivalent with 7+ years or M.Sc. with 10+ years of drug development experience in the pharmaceutical industry.
- Solid background in Oncology clinical biomarkers, expertise in late-phase oncology studies, and translational research within clinical development.
- Strong expertise in cancer biology and clinical development.
- Experience in leading cross-functional teams and designing and executing strategic biomarker plans.
- Experience conducting clinical trials and working as part of clinical study teams.
- Experience designing and executing translational biomarker plans for clinical trials.
Preferred Qualifications:
- M.D., Ph.D. or equivalent doctoral degree in a relevant scientific discipline.
- Experience with high-dimensional dataset analysis.
- Prior experience with diagnostic development and regulatory interactions.
- Experience with digital pathology, AI/ML-enabled biomarker analyses, external scientific partnerships, and mentoring or developing scientific colleagues.
The annual base salary for new hires in this position ranges $189,750 to $316,250. The position offers an annual bonus and eligibility to participate in a share-based long-term incentive program. Available benefits include healthcare and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.