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From the employer's careers site First seen 27 Oct 2026

Principal Software Engineer - Agentic Platform

Salary

$188,000 - $257,500 per year

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Description

We are seeking a Principal Software Engineer to own the underlying agentic platform: the durable orchestration layer on which long-running, multi-agent, multi-model scientific workflows run reliably.

Key Responsibilities:

  • Own the agentic platform end to end, from research prototype to production, building the durable orchestration layer for long-running, multi-stage scientific workflows.
  • Architect workflow orchestration, evaluation frameworks, and event-driven distributed systems that deliver scale, resilience, and reliability.
  • Define SDK abstractions and API contracts between model and agent outputs and downstream consumers, decoupling rapid model iteration from product stability and reducing integration friction across teams.
  • Deliver infrastructure-as-code reference implementations (AWS CDK, Terraform, containerized services) and transform exploratory AI proof-of-concepts into hardened, reusable patterns adopted across product domains.
  • Own platform cost-efficiency and scalability while preserving the performance and accuracy that our experiments and end users require.
  • Explore and template agent design and deployment patterns, and set technical standards, code quality, and architectural direction for the platform.
  • Partner across teams (modeling and agent teams, product) to align on integration points, dependency timelines, and delivery, and mentor engineers and scientists.

Professional Experience & Qualifications:

  • B.S. or M.S. in Computer Science, Engineering, or a related field, with 10+ years of professional software development experience.
  • Demonstrated track record architecting and maintaining large-scale distributed systems in production at technology companies.
  • Deep expertise in workflow orchestration and event-driven architecture, including stateful execution, idempotency, durable retries, and replay.
  • Strong cloud-native engineering on AWS with infrastructure-as-code, containerization, and autoscaling.
  • Proven ability to take systems from prototype to hardened, observable, operationally excellent production.
  • Experience designing SDKs, APIs, and data contracts that serve multiple downstream teams.
  • Excellent communication skills and the ability to build organizational consensus around platform decisions.
  • Collaborative and empathetic working style: listens to understand the needs of scientists, engineers, and downstream teams, and leads through influence.
  • Proven track record setting technical strategy and direction for a growing engineering organization, and mentoring engineers in a fast-moving environment.

Why Join Us:

  • Own the platform foundation for a category-defining autonomous scientific reasoning engine.
  • Take frontier agentic AI from research to dependable production at scale.
  • Collaborate with visionary thinkers and top-tier researchers across Flagship’s ecosystem.
  • Set the technical standards that the broader platform and product teams build on.
  • Shape the future of AI-powered discovery in a role that combines deep engineering excellence with direct human-health impact.

Skills

Required

Nice to have

  • agentic AI
  • Pydantic AI
  • LangGraph
  • LangChain
  • CrewAI
  • AutoGen
  • Anthropic
  • OpenAI
  • Vertex AI
  • Amazon Bedrock
  • LLM observability
  • monitoring tooling
  • cost-governance / FinOps

Ready to apply?

You apply with the employer directly. Their original posting is here: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8584555002

Apply on Flagship Pioneering