Senior Research Associate, In Vitro Screen Execution (Fixed-Term Contract)

Arc Institute is seeking a Senior Research Associate, In Vitro Screen Execution, to join the Cellular Models Technology Center for a fixed term of 12 months.

In this position, you will play a key role in executing protocols to efficiently and reproducibly build and characterize complex 3D models of CNS cells, and leverage these to run high throughput assays and screens.

Responsibilities:

• Execute culture, quality control and validation of complex in vitro 3D neural and glial models.
• Support the execution of high throughput arrayed chemical and genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.
• Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional effects of genetic and chemically perturbed cells within these models.
• Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility.
• Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system.
• Collaborate with other teams at Arc to coordinate screening steps and sample transfer.
• Analyze and present experimental data at internal meetings and seminars.

Requirements:

• BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience.
• Substantial experience culturing and maintaining human PSC-derived cell types or organoids (NPCs, neurons, astrocytes, microglia, or similar).
• Demonstrated ability to execute multiple cell culture protocols with precision.
• Familiarity with maintaining and tracking complex in vitro co-cultures using assays such as imaging, flow cytometry, qPCR, proteomics and transcriptomics-based readouts.
• Excellent aseptic technique and consistent cell-culture practice.
• Meticulous documentation and record-keeping.

Preferred Qualifications:

• Hands-on experience handling high throughput plate formats and automation methods.
• Experience with LIMS systems, ideally Benchling.
• Experience analyzing large data sets preferably using data scripting tools such as Python or R.

The base salary range for this position is $84,250 to $106,000.