Senior Scientist II, Biomolecular Characterization

BigHat Biosciences is seeking an exceptional individual for a Senior Scientist II, Biomolecular Characterization role to drive characterization of in vitro antibody-target binding behavior.

The role involves individual contribution at the bench with strong cross-functional collaboration with scientists, ML/DS, and program teams. You will develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).

Key Responsibilities:

• Develop and implement strategies to characterize antibody-antigen interactions using BLI and SPR
• Design and perform epitope binning assays to cluster antibodies into functional families
• Source, develop, and validate competitive binding/blocking assays to triage candidate antibodies
• Collaborate with the BigHat science organization to accelerate hits from discovery through lead optimization and candidate nomination
• Synthesize and communicate results and research activity to key decision-makers and the broader BigHat team

Skills, Knowledge & Expertise:

• M.Sc/Ph.D. in molecular or cell biology, immunology, or related fields
• 5+ years of advanced, independent research experience in an industry setting
• Substantial experience with the Octet BLI and/or Biacore platforms
• Practical and theoretical fluency with using various BLI sensor types for antibody-antigen binding kinetics and epitope binning
• Deep technical knowledge regarding chip chemistries and characteristics for SPR measurements
• Experience measuring binding interactions with recombinant soluble, transmembrane, and cell-based antigens and various antibody formats
• Strong data analysis and interpretation skills
• Exceptional written, verbal, and visual communication skills
• Ability to educate and build consensus among diverse stakeholders regarding scientific direction

Benefits: The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits.