Scientist, Delivery Screening Technology, Horns Lab

Arc Institute is seeking a Scientist to join the Horns laboratory. The successful candidate will lead the development of pooled screening technology for measuring and engineering how biological nanoparticles deliver molecular cargo into cells.

Responsibilities:

• Design, build, and validate molecular reporters that measure how efficiently delivery vehicles enter cells and release cargo.
• Design and construct pooled libraries of engineered delivery vehicles and cellular components, and execute screens with sequencing-based readouts.
• Scale the platform from proof-of-concept to large multiplexed screens, and apply it to discover and engineer improved delivery vehicles.
• Design and execute validation experiments, including orthogonal assays and characterization of individual hits.
• Analyze sequencing data computationally, including developing analysis pipelines.
• Collaborate with lab members developing complementary screening platforms.
• Maintain accurate and detailed records of experimental protocols, results, and conclusions.
• Present key research findings at internal meetings and seminars, and external conferences.
• Provide guidance and mentorship to Research Associates.
• Stay updated on advancements in the field of functional genomics, synthetic biology, and drug delivery by reading the literature and attending conferences.

Requirements:

• PhD in cell or molecular biology, genetics, biochemistry, bioengineering, or a related field with 0-5 years of relevant post-PhD experience.
• Deep hands-on experience in pooled screening with end-to-end ownership.
• Demonstrated track record of developing and validating novel quantitative molecular assays.
• Fluency with mammalian cell culture and cell engineering.
• Proficiency with flow cytometry.
• Ability to analyze large and complex data sets using Python, R, or similar tools.
• Strong quantitative aptitude and rigorous approach to experimental design.
• Strong project management skills with the ability to plan, execute, and deliver results on time.
• Excellent written and verbal communication skills.

Preferred Qualifications:

• Experience with mammalian synthetic biology, protein engineering, directed evolution, or deep mutational scanning.
• Experience with relevant cell biology or virology.
• Experience with computational protein design or genome mining.
• Experience with animal handling and procedures.

The base salary range for this position is $121,250 to $159,500.