Description
We are seeking an outstanding Associate Director to join us in ideating and building the next generation of Programmable Medicines and lead a team of talented scientists and engineers.
Key Responsibilities:
- Lead LNP scale-up from small R&D formulations to NHP scale in support of a development candidate.
- Drive upstream and downstream process development, including mixing platforms (T-mix, impingement), TFF, and freeze/storage buffer optimization.
- Scale targeted LNPs (tLNPs), including conjugation, purification, and associated analytics.
- Run micro- to mid-scale formulation on microfluidics platforms (e.g., NanoAssemblr) to support platform advancement alongside cross-functional partners.
- Integrate QC profiling and method development (DLS, HPLC/CAD, LC-MS, encapsulation distribution assays) into process development.
- Lead and mentor a team of scientists and engineers, and partner across departments to deliver for in vivo studies.
Qualifications:
- Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering, plus relevant industry experience
- Hands-on experience scaling nucleic acid LNP formulations across upstream, downstream, and analytics
- Working knowledge of mixing platforms (T-mix, impingement, microfluidics) and TFF
- Familiarity with LNP analytical methods (DLS, HPLC/CAD, LC-MS, encapsulation assays)
- Solid understanding of lipid and LNP design principles, stability, and their impact on critical product attributes
- General understanding of molecular biology and nucleic acid therapeutics
- Experience managing and mentoring research associates and junior scientists
Preferred Experience:
- Experience scaling in a GMP environment and managing CDMOs
- Experience taking LNPs to the clinic, including agency interactions
- Experience with tLNP conjugation at scale
- Lipid synthesis, purification, and compositional analysis
The level of the role will be commensurate with the education and years of experience of the identified candidates.
Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.