Scientist/Sr. Scientist, Spatial Omics Technology Development (Fixed-Term Contract)

Arc Institute is seeking a Scientist/Sr. Scientist for a fixed-term contract of 18 months to join the Multi-Omic Technology Center focusing on imaging-based spatial technology development for the Alzheimer's Disease Initiative.

The ideal candidate has a passion for developing technologies and robust systems and has a track record in spatial publications or product development. The role will split between system characterization/improvement and spatial multiomic (mRNA + protein + sgRNA) chemistry/workflow optimization/ execution.

Responsibilities:

• Design and execute system testing and validation plans for the current custom in-house spatial imaging platform.
• Work directly with external vendors to troubleshoot and resolve hardware and software issues.
• Collaborate with the spatial omics project lead and internal partners to optimize spatial multiomic chemistry and sample-prep workflows for human stem-cell-derived brain organoids, adapting protocols validated in mouse tissue.
• Execute end-to-end wet lab spatial perturb-seq workflows.
• Collaborate with computational scientists to analyze imaging QC data and drive iterative assay development and decision-making.
• Track progress against key milestones and report on progress in internal meetings.

Requirements:

• PhD in molecular biology, biochemistry, genomics, bioengineering, or a related field, with 2-5+ years of experience in academia or the biotechnology industry.
• Extensive experience in spatial omics technology and/or product development.
• Hands-on experience with custom imaging and/or fluidic systems, including instrument troubleshooting.
• Hands-on experience with tissue or organoid sample prep and in situ imaging-based assays (e.g., HCR, MERFISH, seqFISH, RCA, in situ sequencing).
• Comfortable working in a fast-paced, early-stage technology development environment with substantial hands-on troubleshooting.
• Strong collaboration and communication skills across multiple teams.
• Strong project management and documentation skills.

Benefits:

• Base salary range: $128,500 to $182,500