Description
We are seeking a Senior Physician Leader to serve as a senior medical expert within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation.
Responsibilities:
- Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation
- Provide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standards
- Interpret complex clinical and safety data, generating insights that inform programme-level decisions led by the CDL
- Partner with the Senior Scientist and cross-functional teams to ensure medical considerations are integrated across study execution and programme delivery
- Provide senior medical input into protocol development and study design, ensuring clinical relevance and patient-centred design within the clinical strategy defined by the CDL
- Serve as a senior member of the CMT, influencing study-level and programme-level decision-making
- Engage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums
- Provide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capability
Detailed Responsibilities:
Medical Monitoring and Safety Oversight
- Guide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit–risk evaluation across the programme
- Participate in and contribute to safety review forums (e.g., SRT, IDMC), providing senior physician perspective on complex safety questions
- Ensure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standards
Study Design and Execution
- Provide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDL
- Guide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or multi-study programmes
- Support resolution of complex medical questions arising during study conduct, applying clinical judgement to inform programme-level decision-making
- Ensure consistency of medical considerations across multiple studies within the programme
Data Interpretation and Scientific Contribution
- Interpret complex clinical data across studies, integrating findings to inform programme-level insights on safety, efficacy, and patient impact
- Contribute to programme-level data interpretation and support CDL-led benefit–risk assessment and clinical positioning
- Guide development of scientific communications, including publications, congress materials, and clinical summaries
- Maintain deep understanding of disease biology, evolving treatment paradigms, and competitive landscape to inform clinical interpretation and programme strategy
Regulatory and External Engagement
- Contribute senior medical expertise to regulatory interactions and Health Authority discussions, including responses to complex clinical and safety queries
- Represent the programme at advisory boards, steering committees, and external scientific forums, providing senior physician perspective on clinical data and programme direction
- Engage with KEEs and scientific collaborators to support programme development, scientific exchange, and external credibility
- Lead or contribute to the clinical and technical diligence assessment of business development opportunities
Cross-Functional Collaboration and Clinical Matrix Team
- Serve as a senior member of the Clinical Matrix Team (CMT), influencing cross-functional alignment and programme-level decision-making
- Contribute medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussions
- Collaborate across functions to ensure alignment on safety, data interpretation, and clinical positioning across the programme
- Lead or contribute to Oncology Clinical Development-wide initiatives and workstreams
People Leadership & Capability Development
- Provide oversight, guidance, and mentorship to Medical Directors within the programme, supporting consistency and quality of medical input across studies
- Support development of clinical capability within the medical team, including coaching on medical monitoring, data interpretation, and external engagement
- Contribute to talent development, performance discussions, and capability building within Oncology Clinical Development
Requirements:
- Medical degree and completion of advanced specialty training, fellowship or country-equivalent higher-level qualification in oncology or haematology
- Experience leading lung cancer drug development, including early phase trials
- Clinical and pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes
- Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies
- Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks
- Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions