Senior Scientist, Developability [Contract]

BigHat Biosciences is seeking a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late-stage drug candidates from its Milliner Platform for AI-designed therapeutics.

This is a lab-based 12-month contract role, with the possibility but no guarantee of conversion to a full-time position. You will spend most of your time at the bench executing complex stability studies.

Key Responsibilities

• Design, lead, and execute in-use dose solution studies to assess drug compatibility with administration materials.
• Develop highly sensitive protein characterization methods, such as qSEC, RP-HPLC, CEX, and particle counting, to evaluate drug quality and recovery.
• Support late-stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates.
• Drive developability assessments, focusing on purity, stability, tolerability, and biophysical properties across programs, with careful attention to data interpretation and organisation.
• Manage and communicate with external CROs for testing and analytics.
• Interpret and communicate scientific findings, propose next steps, and effectively broadcast results across the organisation.
• Proactively identify and explore state-of-the-art analytical tools and developability technologies.

Skills, Knowledge & Expertise

• PhD in Biochemistry or a relevant discipline with 5+ years of industry experience; exceptional non-PhD candidates with extensive bench experience will be considered.
• Experience in developing and optimising sensitive analytical chromatography-based methods is essential.
• Strong background in biophysical and analytical characterisation of antibodies and antibody fragments, including SEC, HIC, CE-SDS, DLS, DSF, ELISA, and LC-MS.
• Proven track record of translating complex data into clear results and actionable recommendations.
• Keenness to learn and onboard new technologies to enhance capabilities, improve work quality, timelines, throughput, or cost.