Description
This role requires an on-site office presence (minimum of two days a week) at one of GSK's Switzerland (Zug), UK (Stevenage or London HQ), or US (PA or MA) sites.
As a Senior Physician Leader, you will serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation.
Key responsibilities include:
- Providing guidance on medical monitoring and safety oversight across studies
- Interpreting complex clinical and safety data to inform programme-level decisions
- Partnering with cross-functional teams to ensure medical considerations are integrated across study execution and programme delivery
- Serving as a senior member of the Clinical Matrix Team (CMT) to influence study-level and programme-level decision-making
- Engaging with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums
The role involves several key areas of responsibility:
Medical Monitoring and Safety Oversight
- Ensuring consistency in approach, patient safety, and protocol adherence
- Guiding interpretation of safety data in collaboration with pharmacovigilance
- Participating in safety review forums to provide senior physician perspective on complex safety questions
Study Design and Execution
- Providing senior medical input into protocol development across studies
- Guiding clinical aspects of study design and protocol implementation
- Supporting resolution of complex medical questions arising during study conduct
Data Interpretation and Scientific Contribution
- Interpreting complex clinical data across studies to inform programme-level insights
- Contributing to programme-level data interpretation and support CDL-led benefit–risk assessment
- Guiding development of scientific communications, including publications, congress materials, and clinical summaries
Regulatory and External Engagement
- Contributing senior medical expertise to regulatory interactions and Health Authority discussions
- Representing the programme at advisory boards, steering committees, and external scientific forums
- Engaging with KEEs and scientific collaborators to support programme development and external credibility
Cross-Functional Collaboration and Clinical Matrix Team
- Serving as a senior member of the CMT to influence cross-functional alignment and programme-level decision-making
- Contributing medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussions
People Leadership & Capability Development
- Providing oversight, guidance, and mentorship to clinical scientists within the programme
- Supporting development of clinical capability within the medical team
Requirements:
- Medical degree and completion of advanced specialty training, fellowship or country-equivalent higher-level qualification in medical oncology, pediatric oncology or hematology
- Experience in sarcoma oncology, including leading drug development
- Clinical and pharmaceutical experience in oncology clinical development
- Experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies
- Understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks
Preferred Qualifications:
- Deep expertise in soft tissue sarcoma and osteosarcoma
- Strong scientific communication and stakeholder engagement skills
- Deep experience in oncology clinical development across multiple studies or programmes
- Experience contributing to or leading aspects of regulatory interactions
- Demonstrated experience engaging with KEEs, advisory boards, and scientific communities in oncology
Salary: If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,250 to $473,750.
Benefits: Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.