Description
The Department of Clinical Pharmacology Modelling & Simulation in Respiratory and Inflammation (CPMS R&I) at GSK is recruiting for a Director–level Clinical Pharmacologist with cardiovascular and metabolic disease expertise.
This role sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation, which aims to be a centre of excellence in Model‑Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling.
You will lead the end‑to‑end application of MIDD across the drug development lifecycle - from first‑in‑human studies through filing and lifecycle management - and provide clinical pharmacology strategy and evidence‑generation input.
Main responsibilities and accountabilities include:
- Design & Execute Model Informed and Clinical Pharmacology strategies
Develop and implement robust MIDD & ClinPharm evidence strategies to de risk and accelerate RIIRU programs.
- Ensure robust ways of working and regulatory ready evidence
Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling.
- Build cross functional partnerships
Work closely with CPQM peers and cross functional partners.
- External engagement & scientific leadership
Raise GSK’s profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora.
Basic Qualifications:
- PhD, MD, or PharmD
- 5+ years of industry experience in clinical pharmacology, modelling/simulation and drug development.
- Experience in pharmacometrics and its application to clinical questions in drug development.
Preferred Qualifications:
- Experience in Cardiovascular and metabolic diseases.
- Demonstrated experience of collaboration in a multi-disciplinary team.
- Evidenced experience making sound judgement in complex situations.
- Experience working with senior stakeholders in a cross functional environment.
- Track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches.
Skills Drug Design, Drug Development, Drug Discovery Process, Drug Discovery Research, Medication Safety, Molecular Modeling, Pharmaceutical Regulatory Compliance, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacometrics, Pharmacovigilance, Study Design, Target Validation