# Director, Oncology Translational Medicine, Clinical Biomarkers

**Company**: GSK
**Location**: Stevenage
**Work arrangement**: hybrid
**Experience**: senior
**Job type**: full-time
**Salary**: $189,750 to $316,250
**Category**: Healthcare
**Industry**: Healthcare

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## Description

The Director, Oncology Translational Medicine, Clinical Biomarkers is responsible for developing and implementing biomarker and translational medicine strategies to support late-stage oncology assets.

As a key member of a Clinical Matrix Team (CMT), the Clinical Biomarker Director will collaborate with the Clinical Biomarker Executive Director to establish clear decision-making criteria, define patient segmentation strategies, and integrate these into clinical development plans.

Key responsibilities:

- Collaborate with the Clinical Biomarker Executive Director to drive the design, alignment, and execution of clinical biomarker and translational medicine strategies.

- Validate and implement biomarker strategies, including target engagement, pharmacodynamic, and proof-of-mechanism biomarkers.

- Participate in tumor-specific Biomarker Matrix teams and execute clinical biomarker strategies for late-stage oncology programs.

- Represent Translational Medicine at Clinical Development Matrix Teams (CMT) to establish biomarker-driven decision-making criteria.

- Support disease area strategies and translational objectives by defining biomarker priorities and generating decision-enabling evidence packages.

- Identify cutting-edge science and technological advances to incorporate into biomarker strategies.

- Oversee and develop sample testing plans and deliver high-quality biomarker data packages.

- Manage effective relationships with cross-functional teams.

- Support the expansion of mechanism and disease understanding to generate insights for indication expansion.

- Define and study mechanisms of resistance to enable reverse translation and inform next-line strategies.

- Contribute to the company's scientific credibility through publications and presentations.

Basic Qualifications:

- Ph.D. or equivalent with 7+ years or M.Sc. with 10+ years of drug development experience in the pharmaceutical industry.

- Solid background in Oncology clinical biomarkers, expertise in late-phase oncology studies, and translational research within clinical development.

- Strong expertise in cancer biology and clinical development.

- Experience in leading cross-functional teams and designing and executing strategic biomarker plans.

- Experience conducting clinical trials and working as part of clinical study teams.

- Experience designing and executing translational biomarker plans for clinical trials.

Preferred Qualifications:

- M.D., Ph.D. or equivalent doctoral degree in a relevant scientific discipline.

- Experience with high-dimensional dataset analysis.

- Prior experience with diagnostic development and regulatory interactions.

- Experience with digital pathology, AI/ML-enabled biomarker analyses, external scientific partnerships, and mentoring or developing scientific colleagues.

The annual base salary for new hires in this position ranges $189,750 to $316,250. The position offers an annual bonus and eligibility to participate in a share-based long-term incentive program. Available benefits include healthcare and other insurance benefits, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

## Skills

### Required
- Analytical Thinking
- Clinical Data Interpretation
- Clinical Data Review
- Clinical Development
- Clinical Trial Designs
- Clinical Trials Monitoring
- Digital Fluency
- Drug Regulatory Affairs
- Executive Presence
- Hematology and Oncology
- Learning Agility
- Matrix Leadership
- Real World Evidence (RWE)
- Scientific Presentations

### Nice to have
- high-dimensional dataset analysis
- diagnostic development
- regulatory interactions
- digital pathology
- AI/ML-enabled biomarker analyses
- external scientific partnerships
- mentoring or developing scientific colleagues

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