# Pioneering Medicines: Medical Director / Senior Medical Director, Clinical Development Lead

**Company**: Pioneering Medicines
**Location**: Cambridge, MA
**Work arrangement**: hybrid
**Experience**: senior
**Job type**: full-time
**Salary**: $215,000 - $335,000
**Category**: Healthcare
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8766386002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_dcf02848-1ed

## Description

Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing life-changing treatments for patients built from Flagship's innovative platforms.

The Clinical Development Lead (Medical Director or Senior Medical Director level) is a Physician-Scientist who plays a pivotal role on Pioneering Medicines (PM) project teams by driving the successful transition of programs from research into early clinical development.

Responsibilities:

- Lead the design of early clinical development plans (through human proof-of-concept) for PM programs, in alignment with the Target Product Profile (TPP).

- Collaborate closely with senior clinical leaders, Project Leaders, Research, Strategy, and external advisors/KOLs to define and refine clinical hypotheses and development strategies.

- Integrate clinical plans with translational, nonclinical, and regulatory development strategies to enable seamless progression from exploratory studies to first-in-human trials.

- Partner with Research teams,including Pharmacology, Translational Sciences, and Nonclinical Development,to align research outputs with clinical objectives.

- Work with the Strategy Group to ensure clinical plans support the TPP and the overall program value proposition.

- Incorporate regulatory input, operational feasibility, and real-world data to ensure robust and executable development strategies.

- Collaborate with Project Management to develop integrated timelines, resource forecasts, and budget assumptions for incorporation into NewCo planning.

- Support the preparation and delivery of key materials for internal governance forums and Joint Steering Committees (JSCs) with external partners.

- Identify and address development risks and bottlenecks proactively; drive resolution across functional interfaces.

- Promote a culture of scientific rigor, accountability, agility, and open collaboration within project teams.

- Enhance cross-functional integration by facilitating communication, alignment, and shared ownership of development goals.

Qualifications:

- Physician Scientist: MD or MD with PhD with a robust scientific background.

- 3+ years or more of post-graduate/post-residency experience in industry or academic clinical research.

- Medical residency completion required.

- Subspecialty fellowship training is highly preferred.

- Strong understanding of early clinical development and translational medicine, mechanisms of disease, and patient care paradigms in relevant therapeutic areas (oncology, immunology, and/or metabolic diseases preferred).

- Demonstrated excellence in scientific rigor, operational decision making, risk mitigation, and innovation.

- Proven leadership and effective communication skills, with the ability to collaborate and convey strategic implications to diverse stakeholders.

- Excellent oral, written, and presentation skills for engaging stakeholders and fostering teamwork.

- Strong strategic thinking and critical thinking skills for identifying and addressing bottlenecks while optimizing cross-functional processes.

- Proactive and adaptable in demanding environments, with an operational mindset to improve efficiency and achieve strategic goals.

Benefits:

- Healthcare coverage.

- Annual incentive program.

- Retirement benefits.

- Broad range of other benefits.

## Skills

### Required
- MD
- PhD
- clinical research
- translational medicine
- regulatory development

### Nice to have
- oncology
- immunology
- metabolic diseases

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Source: [Apply at job-boards.greenhouse.io](https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8766386002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)