# Scientist, In Vivo Pharmacology

**Company**: Serif Biomedicines
**Location**: Cambridge, MA
**Experience**: senior
**Job type**: full-time
**Salary**: $100,000 - $143,000
**Category**: Research
**Industry**: Healthcare

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## Description

We are looking for an experienced scientist to join the in vivo pharmacology group at Serif.

This position will report to the head of pharmacology and will focus on executing preclinical studies in rodent models, including humanized mouse models, to support exploratory and therapeutic programs, both internally and in collaboration with CROs.

Key Responsibilities:

- Execute and oversee in vivo efficacy, biodistribution, PK/PD in rodent models including humanized mice, xenograft, syngeneic, and transgenic mouse models relevant to platform and therapeutic programs.

- Contribute to study designs, study planning, and resource allocation of in vivo studies by working in close collaboration with head of Pharmacology.

- Perform animal procedures including blood collection, necropsy, tissue harvest, and homogenization, cell isolation, and test article administration through multiple routes.

- Establish and maintain strong relationships with vivarium and external CRO to ensure high quality and timely execution of studies.

- Perform dose calculations and prepare dosing formulations for rodent and NHP studies.

- Ensure study compliance with IACUC protocols, and company policies.

- Maintain accurate experimental records, study protocols and reports.

- Demonstrate scientific and technical expertise to advance in vivo studies through familiarity with scientific literature.

- Proactively recognize and develop creative solutions for emerging technical and scientific issues.

- Analyze relevant tolerability endpoints and effectively communicate results to stakeholders.

Required Qualifications:

- M.S with 10+ or B.S with 12+ years industry experience, respectively.

- Proficient hands-on experience in mouse models of immunology, oncology and transgenic reporter models.

- Experience in writing IACUC protocols required.

- Experience performing in-vivo procedures in rodents, including dose preparation and administration of therapeutics and sample collection.

- Strong organizational, communication and interpersonal skills.

- Ability to thrive in a fast-paced, and rapidly growing biotech environment with changing priorities.

Benefits:

- Healthcare coverage

- Annual incentive program

- Retirement benefits

## Skills

### Required
- in vivo pharmacology
- rodent models
- IACUC protocols
- animal procedures
- study design

### Nice to have
- IVIS acquisition and analysis
- NHP protocols

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