# Research Associate I/II, Protein Sciences

**Company**: Flagship Labs 109, Inc.
**Location**: Cambridge, MA
**Work arrangement**: onsite
**Experience**: entry
**Job type**: full-time
**Salary**: $65,000 - $93,500
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8935620002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
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## Description

We are seeking a highly motivated Research Associate to support recombinant protein production at Fathem. This role will focus on the expression, purification, and characterization of challenging protein targets,including membrane proteins and other cryo-EM–ready samples,with an emphasis on high-throughput, high-quality data generation.

You will work at the intersection of protein biochemistry, structural biology, and AI-driven technology development, building robust purification workflows and characterization assays that directly feed data into next-generation computational models.

**Basic requirements**

- Bachelor’s degree in Biochemistry or a related field, with a minimum of 2 years relevant experience in an academic or industry laboratory or a MS degree in Biochemistry or a related field

- Hands-on experience in recombinant protein expression and purification, encompassing all steps of the end-to-end workflow: transformation/transfection, and the full range of chromatographic techniques (affinity, ion-exchange, and size-exclusion).

- Familiarity with protein construct design and analytical techniques used to assess recombinant protein quality, including size-exclusion chromatography, dynamic light scattering, and thermostability assays.

- Proven ability to rigorously document their work in an ELN and maintain lab organization and inventories.

**Strong candidates will have:**

- More than one year of experience with recombinant protein production and purification in an industry setting.

- Proficiency with ÄKTA systems and UNICORN software, including the design and execution of protein purification methods.

- Experience implementing protein characterization and binding assays, e.g. ELISA, BLI, and/or enzymatic activity.

- Proficiency across multiple protein expression systems, such as bacterial, mammalian, insect, yeast, and/or cell-free platforms.

- Experience generating proteins for high-resolution cryo-electron microscopy (cryo-EM) applications.

- Demonstrated expertise in the purification and characterization of membrane proteins.

- Experience with automation in a biochemistry context, such as automated protein purification or high-throughput assay development.

- Experience with antibody or antibody fragment production and purification.

The salary range for this role is $65,000 - $93,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Fathem, Inc currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

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## Skills

### Required
- Biochemistry
- Recombinant protein expression
- Purification
- Characterization
- Protein construct design
- Analytical techniques
- Documentation
- Lab organization

### Nice to have
- ÄKTA systems
- UNICORN software
- ELISA
- BLI
- Enzymatic activity
- Multiple protein expression systems
- Cryo-electron microscopy
- Membrane protein purification
- Automation
- Antibody production

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