# Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling **Company**: ViiV Healthcare (GSK) **Location**: Branford, CT **Work arrangement**: hybrid **Experience**: senior **Job type**: full-time **Salary**: $141,075 to $235,125 **Category**: Healthcare **Industry**: Healthcare **Apply**: https://gsk.wd5.myworkdayjobs.com/en-US/GSKCareers/job/USA---Connecticut---Branford/ViiV-Healthcare--GSK--Scientific-Leader--Pre-clinical-DMPK-Drug-Discovery-Modeling_447561-1?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply **Canonical**: https://yubhub.co/jobs/job_cd0ea721-29e ## Description ViiV Healthcare, a global specialty HIV company, is seeking a Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling. This role will drive model-informed drug discovery across ViiV's Drug Discovery organization by developing and applying fit-for-purpose modeling and simulation approaches. The successful candidate will serve in a matrix leadership role, partnering closely with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early dose predictions and guide the design and selection of high-quality clinical candidates. Responsibilities: - Develop and apply fit-for-purpose mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide drug discovery teams toward the highest-quality clinical candidates - Translate complex ADME, PK, PD, and translational data into actionable insights for project teams and senior leadership - Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies - Build scalable computational tools, workflows, and prototypes that accelerate discovery decisions and candidate optimization - Establish best practices, standards, and governance for modeling methodologies, tools, and computational workflows - Contribute to scientific publications, regulatory submissions, and other technical documentation, and represent ViiV externally through regulatory interactions and scientific thought leadership Requirements: - Master's degree with 7 or more years of post-graduate experience, or a PhD with 4 or more years of post-graduate experience, supporting drug discovery programs from lead optimization to Phase I clinical studies - Strong understanding of ADME principles and integration of standard DMPK workflows and data streams into empirical and mechanistic modeling and simulation approaches - Demonstrated ability to apply modeling and simulation approaches to influence key drug discovery decisions - Broad computational programming expertise in programming and modeling languages (e.g., R, Python) and modeling platforms (e.g., Simcyp, GastroPlus) - Experience integrating diverse datasets into unified predictive modeling platforms - Ability to interpret and communicate modeling results to cross-functional teams Preferred Qualifications: - PhD with 6 or more years of drug discovery experience in DMPK or a related discipline - Demonstrated experience developing and applying modeling and simulation strategies across diverse modalities and routes of administration - Experience working across teams, including matrix and functional leadership - Excellent written, verbal, and presentation skills - Experience in infectious disease and/or immunology therapeutic areas Benefits: - Annual base salary ranging from $141,075 to $235,125 - Annual bonus and eligibility to participate in share-based long-term incentive program - Health care and other insurance benefits - Retirement benefits - Paid holidays, vacation, and paid caregiver/parental and medical leave ## Skills ### Required - ADME - PBPK Modeling - Pharmacokinetics - Pharmacology - Drug Discovery Process ### Nice to have - infectious disease - immunology - matrix and functional leadership --- Source: [Apply at gsk.wd5.myworkdayjobs.com](https://gsk.wd5.myworkdayjobs.com/en-US/GSKCareers/job/USA---Connecticut---Branford/ViiV-Healthcare--GSK--Scientific-Leader--Pre-clinical-DMPK-Drug-Discovery-Modeling_447561-1?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)