# Senior Research Associate, In Vitro Screen Execution (Fixed-Term Contract)

**Company**: Arc Institute
**Location**: Palo Alto, CA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: contract
**Salary**: $84,250 to $106,000
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/arcinstitute/jobs/6174274004?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
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## Description

Arc Institute is seeking a Senior Research Associate, In Vitro Screen Execution, to join the Cellular Models Technology Center for a fixed term of 12 months.

In this position, you will play a key role in executing protocols to efficiently and reproducibly build and characterize complex 3D models of CNS cells, and leverage these to run high throughput assays and screens.

Responsibilities:

- Execute culture, quality control and validation of complex in vitro 3D neural and glial models.

- Support the execution of high throughput arrayed chemical and genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.

- Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional effects of genetic and chemically perturbed cells within these models.

- Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility.

- Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system.

- Collaborate with other teams at Arc to coordinate screening steps and sample transfer.

- Analyze and present experimental data at internal meetings and seminars.

Requirements:

- BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience.

- Substantial experience culturing and maintaining human PSC-derived cell types or organoids (NPCs, neurons, astrocytes, microglia, or similar).

- Demonstrated ability to execute multiple cell culture protocols with precision.

- Familiarity with maintaining and tracking complex in vitro co-cultures using assays such as imaging, flow cytometry, qPCR, proteomics and transcriptomics-based readouts.

- Excellent aseptic technique and consistent cell-culture practice.

- Meticulous documentation and record-keeping.

Preferred Qualifications:

- Hands-on experience handling high throughput plate formats and automation methods.

- Experience with LIMS systems, ideally Benchling.

- Experience analyzing large data sets preferably using data scripting tools such as Python or R.

The base salary range for this position is $84,250 to $106,000.

## Skills

### Required
- cell culture
- molecular biology
- in vitro assays
- data analysis
- documentation

### Nice to have
- high throughput plate formats
- automation methods
- LIMS systems
- data scripting tools

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