# Senior Scientist II, Biomolecular Characterization

**Company**: Bighatbiosciences
**Location**: San Mateo, CA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full time
**Salary**: $145,000 - $165,000
**Category**: Lab Science
**Industry**: Healthcare

**Apply**: https://bighatbiosciences.pinpointhq.com/en/postings/9b5ebce7-90fd-475b-906d-37d32981eb2e?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_b23f134a-bf3

## Description

BigHat Biosciences is seeking an exceptional individual for a Senior Scientist II, Biomolecular Characterization role to drive characterization of in vitro antibody-target binding behavior.

The role involves individual contribution at the bench with strong cross-functional collaboration with scientists, ML/DS, and program teams. You will develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).

Key Responsibilities:

- Develop and implement strategies to characterize antibody-antigen interactions using BLI and SPR

- Design and perform epitope binning assays to cluster antibodies into functional families

- Source, develop, and validate competitive binding/blocking assays to triage candidate antibodies

- Collaborate with the BigHat science organization to accelerate hits from discovery through lead optimization and candidate nomination

- Synthesize and communicate results and research activity to key decision-makers and the broader BigHat team

Skills, Knowledge & Expertise:

- M.Sc/Ph.D. in molecular or cell biology, immunology, or related fields

- 5+ years of advanced, independent research experience in an industry setting

- Substantial experience with the Octet BLI and/or Biacore platforms

- Practical and theoretical fluency with using various BLI sensor types for antibody-antigen binding kinetics and epitope binning

- Deep technical knowledge regarding chip chemistries and characteristics for SPR measurements

- Experience measuring binding interactions with recombinant soluble, transmembrane, and cell-based antigens and various antibody formats

- Strong data analysis and interpretation skills

- Exceptional written, verbal, and visual communication skills

- Ability to educate and build consensus among diverse stakeholders regarding scientific direction

Benefits: The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits.

## Skills

### Required
- biolayer interferometry
- surface plasmon resonance
- antibody-antigen binding kinetics
- epitope binning
- lab automation

### Nice to have
- experience managing teams
- mentorship of junior scientists

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Source: [Apply at bighatbiosciences.pinpointhq.com](https://bighatbiosciences.pinpointhq.com/en/postings/9b5ebce7-90fd-475b-906d-37d32981eb2e?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)