# Scientist, Delivery Screening Technology, Horns Lab

**Company**: Arc Institute
**Location**: Palo Alto, CA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full-time
**Salary**: $121,250 to $159,500
**Category**: Research
**Industry**: Other

**Apply**: https://job-boards.greenhouse.io/arcinstitute/jobs/6204376004?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_9e59a7e1-054

## Description

Arc Institute is seeking a Scientist to join the Horns laboratory. The successful candidate will lead the development of pooled screening technology for measuring and engineering how biological nanoparticles deliver molecular cargo into cells.

Responsibilities:

- Design, build, and validate molecular reporters that measure how efficiently delivery vehicles enter cells and release cargo.

- Design and construct pooled libraries of engineered delivery vehicles and cellular components, and execute screens with sequencing-based readouts.

- Scale the platform from proof-of-concept to large multiplexed screens, and apply it to discover and engineer improved delivery vehicles.

- Design and execute validation experiments, including orthogonal assays and characterization of individual hits.

- Analyze sequencing data computationally, including developing analysis pipelines.

- Collaborate with lab members developing complementary screening platforms.

- Maintain accurate and detailed records of experimental protocols, results, and conclusions.

- Present key research findings at internal meetings and seminars, and external conferences.

- Provide guidance and mentorship to Research Associates.

- Stay updated on advancements in the field of functional genomics, synthetic biology, and drug delivery by reading the literature and attending conferences.

Requirements:

- PhD in cell or molecular biology, genetics, biochemistry, bioengineering, or a related field with 0-5 years of relevant post-PhD experience.

- Deep hands-on experience in pooled screening with end-to-end ownership.

- Demonstrated track record of developing and validating novel quantitative molecular assays.

- Fluency with mammalian cell culture and cell engineering.

- Proficiency with flow cytometry.

- Ability to analyze large and complex data sets using Python, R, or similar tools.

- Strong quantitative aptitude and rigorous approach to experimental design.

- Strong project management skills with the ability to plan, execute, and deliver results on time.

- Excellent written and verbal communication skills.

Preferred Qualifications:

- Experience with mammalian synthetic biology, protein engineering, directed evolution, or deep mutational scanning.

- Experience with relevant cell biology or virology.

- Experience with computational protein design or genome mining.

- Experience with animal handling and procedures.

The base salary range for this position is $121,250 to $159,500.

## Skills

### Required
- pooled screening
- mammalian cell culture
- cell engineering
- flow cytometry
- Python
- R
- quantitative molecular assays
- project management

### Nice to have
- mammalian synthetic biology
- protein engineering
- directed evolution
- deep mutational scanning
- computational protein design
- genome mining
- animal handling

---

Source: [Apply at job-boards.greenhouse.io](https://job-boards.greenhouse.io/arcinstitute/jobs/6204376004?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)