# Scientist, Cellular Immunology and Inflammation

**Company**: Prologue Medicines
**Location**: Cambridge, MA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full-time
**Salary**: $100,000 - $143,000
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8937790002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/job/scientist-cellular-immunology-and-inflammation-9d97e8b5-428/

## Description

Prologue Medicines is seeking a highly motivated, focused, and creative Scientist, Cellular Immunology and Inflammation to join our Research and Discovery team.

You will advance therapeutic discovery programs by designing, developing and running cellular immunology and inflammation studies that support target validation, biological characterization and mechanism-of-action investigations.

Key Responsibilities:

- Independently design, execute and analyze in vitro and ex vivo cellular immunology and inflammation experiments that support target validation, therapeutic discovery and mechanistic investigations.

- Develop, optimize and implement robust cell-based assays to evaluate immune cell activation, differentiation, proliferation, signaling, inflammatory responses and functional outputs.

- Apply multiparameter flow cytometry expertise, including panel design, staining optimization, data acquisition, analysis and cell sorting, to characterize immune cell populations and biological responses.

- Isolate, culture and manipulate primary human and/or animal immune cells, including innate and adaptive populations, using established techniques.

- Design and execute phenotypic and mechanism-of-action studies to investigate immune and inflammatory pathways, validate therapeutic targets and test biological hypotheses.

- Apply complementary readouts to characterize cellular responses and assess therapeutic activity, including transcriptomic profiling and biomarker and cytokine assays.

- Critically analyze experimental data, troubleshoot assay performance and recommend follow-up experiments to inform discovery program decisions.

- Collaborate with cross-functional research teams to integrate cellular immunology findings into broader discovery and translational research strategies.

- Develop and maintain experimental protocols, assay documentation and laboratory best practices that ensure scientific rigor, reproducibility and data integrity.

- Present experimental findings, scientific interpretations and recommendations to cross-functional teams and leadership through presentations, technical discussions and written reports.

- Stay current with emerging scientific literature, technologies and methodologies in cellular immunology, inflammation and therapeutic discovery.

Required Qualifications:

- PhD in Immunology, Cell Biology, Molecular Biology or a related biological discipline, or an M.Sc. with 6+ years of directly relevant experience in cellular immunology.

- Demonstrated hands-on expertise with patient-derived tissues and primary immune cells.

- Strong proficiency in multiparameter flow cytometry.

- Proven experience developing, optimizing and troubleshooting cell-based functional and mechanistic assays.

- Strong understanding of immune cell biology, immune and inflammatory signaling pathways, and the mechanisms underlying innate and adaptive immune responses.

- Experience with immunological and biomarker readouts performed in singleplex and multiplex formats.

- Demonstrated ability to design experiments independently, critically evaluate results and translate scientific findings into actionable recommendations.

- Proficiency in quantitative data analysis and statistical interpretation.

- Excellent organizational, problem-solving, communication and presentation skills.

- Ability to work independently and collaborate effectively as part of team-based, matrixed, multidisciplinary research teams in a dynamic laboratory environment.

The salary range for this role is $100,000 - $143,000.

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## Skills

### Required
- cellular immunology
- inflammation
- multiparameter flow cytometry
- immune cell biology
- assay development
- data analysis
- scientific writing
- presentation skills

### Nice to have
- biotechnology
- pharmaceutical research
- single-cell approaches
- genomic analysis
- bioinformatics
- CRISPR knockout
- plate-based assay formats

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