# Senior Scientist, Bioanalytical Sciences

**Company**: Serif Biomedicines
**Location**: Cambridge, MA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full-time
**Salary**: $126,000 - $181,500
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8872070002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_8eea6482-d62

## Description

We are seeking a highly motivated and accomplished Sr. Scientist I with deep expertise in innate immunogenicity, and bioanalytical assay development, including ligand binding assays (LBA) and multi-color flow cytometry.

In this role, you will lead the development, qualification, and implementation of various immunogenicity and LBAs that support both our platform and therapeutic programs, with a particular focus on characterizing innate immune responses to novel nucleic acid modalities.

Key Responsibilities:

- Design, develop and execute cell-based immunoassays, flow cytometry based assays and LBAs to assess immunogenicity to LNP delivered nucleic acid cargoes in vitro and in vivo

- Apply knowledge of innate immunology and establish in vitro screening assays for various nucleic acid modalities and establish criteria for release of cargo for pre-clinical research

- Collaborate closely with CMC, molecular biology and cell biology teams to screen nucleic acid cargoes (immunogenicity assessment etc.) and ensure timely delivery of high-quality data and summarize results

- Ensure development, qualification, and validation of bioanalytical assays in compliance with applicable guidelines

- Design, optimize, and execute biodistribution studies (flow cytometry and histological techniques) for LNP/nucleic acid therapies

- Design, establish and execute assays for assessing various in vivo immunogenicity predictors for LNP/nucleic acid therapies including but not limited to biomarkers, cytokines, complement activation and anti-drug antibodies (ADA) in rodents and NHPs

- Design, develop, optimize, and execute bioanalytical assays to support nonclinical studies, including PK, PD, biomarker, and immunogenicity endpoints

- Execute test procedures such as sample extraction and measurement by Flow Cytometry, ELISA, MSD, Luminex, bDNA, ddPCR and perform data interpretation

- Analyze and summarize scientific data and maintain timely documentation and completion of electronic lab notebooks in compliance with industry guidelines

- Present at project team meetings and to relevant stakeholders

- Mentor, coach, and manage junior scientists

Qualifications:

- Ph.D. in immunology, biochemistry, pharmaceutical sciences, cell biology or related field with 5 plus years of industry experience

- Demonstrated expertise in innate immune signaling and nucleic acid sensing pathways for DNA and mRNA

- Proficiency in multicolor flow cytometry, ddPCR, ligand binding assays, leukopak processing and isolation of PBMCs

- Experience with LNPs, and nucleic acid modalities preferred

- Experience developing bioanalytical methods to measure drugs and biomarkers for LNP delivery of nucleic acid cargoes

- Experience managing junior scientists

- Strong communication, presentation and interpersonal skills

- Attention to detail, strategic thinking, problem solving, and decision-making skills

The salary range for this role is $126,000 - $181,500. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

## Skills

### Required
- innate immunogenicity
- bioanalytical assay development
- ligand binding assays
- multi-color flow cytometry
- immunology
- biochemistry
- pharmaceutical sciences
- cell biology

### Nice to have
- LNPs
- nucleic acid modalities
- bioanalytical methods

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