# Senior Clinical Data Science Lead **Company**: ICON Strategic Solutions **Location**: Reading **Experience**: senior **Job type**: full-time **Category**: Data Science **Industry**: Healthcare **Apply**: https://icon.wd3.myworkdayjobs.com/en-US/broadbean_external/job/UK-Reading/Senior-Clinical-Data-Science-Lead_JR163549?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply **Canonical**: https://yubhub.co/jobs/job_8b355d12-090 ## Description As a Senior Clinical Data Science Lead at ICON, you will lead the analysis, interpretation, and management of clinical data to drive the success of our clinical trials. **Responsibilities:** - Leading Clinical Data Management activities across assigned studies, from study start-up through to database closure and clean database declaration. - Providing oversight and guidance to Data Management staff assigned to specific protocols, including mentoring and training less experienced colleagues. - Acting as an experienced Clinical Data Management resource for global, cross-functional study teams and serving as an escalation point for study-related data management matters. - Developing and maintaining study-specific data management components and specifications, including eCRFs, study metadata, edit checks, Data Validation Documents, and protocol deviation documentation. - Collaborating with EDC developers on the specification and design of eCRFs and database structures and contributing to EDC User Acceptance Testing (UAT). - Managing data cleaning activities, including identifying and issuing queries, incorporating query responses, tracking query status, and performing consistency checks on external data. - Coordinating SAS programming requirements for edit checks and derivations and contributing to the preparation of data monitoring activities. - Preparing data listings and extracts to support medical reviews, study reporting, and other cross-functional activities. - Developing and coordinating database closure plans and ensuring database closure activities are effectively communicated and delivered across the study team. - Identifying and communicating issues that could impact study timelines or data quality and working collaboratively with study teams to address them. - Ensuring Clinical Data Management activities are appropriately documented throughout the lifecycle of the study. - Supporting training and education initiatives for Data Management colleagues to promote quality, productivity, and consistent working practices. **Requirements:** - Bachelor's degree or equivalent in Natural Sciences, Informatics, Medical Documentation, or a related discipline. - 5+ years of experience as a Clinical Data Manager, with significant responsibility within clinical projects and study teams. - Strong understanding of the drug development process and extensive experience with clinical data management methodologies and technologies. - Proven experience managing clinical data from study start-up through to clean database declaration. - Experience working within global, cross-functional teams and collaborating with functions such as Study Management, Medical, EDC Development, Statistics, and Medical Writing. - Demonstrated ability to interpret Clinical Study Protocols, Statistical Analysis Plans, and Medical Review Plans and translate these into appropriate data management specifications. - Experience developing specifications including CRFs, metadata, protocol deviation documents, and edit check specifications. - Good understanding of relevant clinical research regulations and guidelines, including ICH and GCP. - Experience training and/or mentoring junior Data Management colleagues, with the ability to provide guidance and act as an escalation point. - Strong project management, organisational, and self-management skills, with the ability to work independently and effectively manage priorities. - Experience working within and helping lead global, cross-functional teams towards key study milestones such as First Patient First Visit readiness and timely clean database declaration. - Strong written and verbal communication skills in English, with fluent spoken English required, alongside strong local-language communication skills. - Good understanding of IT processes and databases used within Clinical Development. - A proactive approach to continuous learning and professional development. **Rewards & Benefits:** - Competitive base salary and performance-related incentives - Health and wellbeing programmes including medical, dental, and vision coverage where applicable - Retirement and pension plans - Life assurance and disability coverage - Employee assistance programmes and wellbeing resources - Learning and development opportunities through structured training and career pathways ## Skills ### Required - Clinical Data Management - Data Analysis - Interpretation - Management - Clinical Trials - eCRFs - study metadata - edit checks - Data Validation Documents - protocol deviation documentation - EDC developers - SAS programming - data monitoring activities - data listings - extracts - database closure plans - ICH - GCP - Natural Sciences - Informatics - Medical Documentation --- Source: [Apply at icon.wd3.myworkdayjobs.com](https://icon.wd3.myworkdayjobs.com/en-US/broadbean_external/job/UK-Reading/Senior-Clinical-Data-Science-Lead_JR163549?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)