# Senior Development Scientist I

**Company**: Freenome
**Location**: Brisbane, California
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full-time
**Category**: Science
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/freenome/jobs/8691772002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_89affac3-6b9

## Description

At Freenome, we are seeking a Senior Development Scientist I to help grow the Freenome Genomics Late Development team.

You will develop, optimize, verify, and validate clinical-grade assay technologies for Freenome's multiomic platform, advancing our mission to detect cancer earlier.

Working across manual and automated workflows, you will collaborate with cross-functional teams to develop and transfer robust NGS-based assays into a regulated, high-throughput production environment.

**Responsibilities**

- Apply knowledge of molecular biology, nucleic-acid biochemistry, and next-generation sequencing to develop assays for DNA, including genome-wide and targeted approaches.

- Oversee and lead mission-critical experiments to optimize, characterize, verify, and validate NGS-based assays, owning scientific strategy, experimental design, planning, timelines, execution, and delivery.

- Design and execute high-impact experiments, generate detailed documentation, perform data analysis, create summary presentations, and present results cross-functionally.

- Troubleshoot complex technical challenges, identify root causes, and drive process improvements to assay performance and laboratory workflows.

- Drive project planning and prioritization by defining milestones, identifying and mitigating risks, and adapting to evolving program needs.

- Build productive working relationships and partner cross-functionally with computational scientists, engineers, and clinical laboratory team members to transition development protocols into clinical production, including automation, validation experiments, and SOP development.

- Document product development requirements and author study protocols and reports.

**Requirements**

- PhD in molecular biology, biochemistry, genetics, or a related field with at least 4 years of professional experience in the life sciences, or a Bachelors or Masters degree with at least 10 years of professional experience.

- Prior experience in clinical diagnostics and/or working in a start-up environment is preferred.

- Experience designing and leading the execution of verification and validation studies for IVD assays in a regulated clinical laboratory environment (GLP).

- Extensive hands-on experience in Next-gen sequencing (NGS) based automated assay development including extraction, library preparation, target capture, and sequencing.

- Experience working with automated platforms and liquid handlers.

- Extensive hands-on experience in nucleic acid preparation, amplification, and quantification (DNA/RNA extraction and purification, PCR, qPCR, Qubit, Fragment Analyzer, Tapestation).

- Experience in working with ctDNA/cfDNA as an analyte in NGS workflows.

- Proven track record of designing, planning, and executing successful experiments, including performing independent data analysis and giving effective scientific presentations.

- High attention to detail and ability to record accurate and detailed observations, assess impact, and lead independent troubleshooting investigations.

- Excellent written and verbal communication.

- Proactive communicator with ability to foster collaboration in a multidisciplinary team.

- Flexible and highly motivated to learn new skills and comfortable adapting to changing priorities.

- Experience providing technical mentorship and training to other scientists and research associates to contribute to a culture of technical excellence and continuous improvement.

**Benefits**

- The US target range of our base salary rate for new hires is (Insert range here, low of Tier 3 and high of Tier 1).

- You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.

## Skills

### Required
- molecular biology
- nucleic-acid biochemistry
- next-generation sequencing
- NGS-based assay development
- automated assay development
- library preparation
- target capture
- sequencing
- nucleic acid preparation
- amplification
- quantification
- ctDNA/cfDNA analysis

### Nice to have
- methylated ctDNA/cfDNA analysis
- scientific programming
- data analysis tools
- Python
- R

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Source: [Apply at job-boards.greenhouse.io](https://job-boards.greenhouse.io/freenome/jobs/8691772002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)