# Research Associate, In Vivo

**Company**: FL106 Inc.
**Location**: Cambridge, MA
**Experience**: entry
**Job type**: full-time
**Salary**: $65,000 - $93,500
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8855856002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_8138fccf-983

## Description

We are seeking a highly motivated Research Associate with broad expertise conducting in vivo studies, histology preparation and analysis, and molecular biology.

This individual will play an important role in generating high-quality data on the biodistribution, target engagement, and biological response of our molecules in animal models.

**Key Responsibilities:**

- In Vivo Pharmacology:

- Conduct in vivo studies in rodent models including experience with peripheral administration (IV, IP, SC) and stereotactic surgeries for direct to CNS administration.

- Conduct terminal procedures, including animal takedowns, blood collection, and necropsies.

- Perform tissue harvesting and dissection as appropriate for downstream bioanalytical and histological applications.

- Histology & Imaging:

- Prepare, embed, and section a variety of mammalian tissues using microtome, vibratome, or cryostat techniques (FFPE or fresh-frozen samples).

- Perform immunohistochemistry (IHC) and immunofluorescence (IF) on tissue sections.

- Acquire high-quality images using epifluorescence and/or confocal microscopy.

- Perform in vivo and ex vivo fluorescence and bioluminescence imaging using IVIS or equivalent small-animal imaging systems, including organ collection, image acquisition, and quantitative analysis of signal intensity and tissue distribution.

- Conduct quantitative image analysis (cell counts, regional MFI, colocalization analysis, morphometric quantification) using software such as ImageJ, QuPath, Halo, or equivalent platforms.

- Molecular Biology:

- Perform measurement of gene and protein expression analyses using qRT-PCR, Western blotting, and ELISA methodologies and interpret data.

- Report results clearly to the scientific team.

**Qualifications and Skills:**

- Bachelor’s degree or higher in Cell Biology or a related field, with 1+ years of laboratory experience, preferably in the biopharmaceutical industry.

- Strong hands-on experience with rodent in vivo studies.

- Strong hands-on experience in histology, including tissue embedding, sectioning, staining, IHC/IF, and imaging.

**Additional Qualifications (preferred but not required):**

- Authorship on a peer reviewed publication.

- Experience with multiplex IHC/IF and advanced image analysis platforms.

**Benefits:**

- Healthcare coverage.

- Annual incentive program.

- Retirement benefits.

- A broad range of other benefits.

## Skills

### Required
- in vivo studies
- histology
- molecular biology
- rodent models
- immunohistochemistry
- immunofluorescence
- microscopy
- image analysis
- qRT-PCR
- Western blotting
- ELISA

### Nice to have
- multiplex IHC/IF
- advanced image analysis platforms
- authorship on a peer reviewed publication

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