# Senior Director, Project and Alliance Management **Company**: Prologue Medicines **Location**: Cambridge, MA **Experience**: senior **Job type**: full-time **Salary**: $213,000 - $280,500 **Category**: Operations **Industry**: Healthcare **Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8941051002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply **Canonical**: https://yubhub.co/job/senior-director-project-and-alliance-management-7b9cd854-40f/ ## Description Prologue Medicines, a Flagship Pioneering company, is building a new class of medicines from the viral proteome: the millions of proteins viruses have evolved to engage and regulate human biology. Its DELVE platform combines a viral-protein knowledge graph and computational design with high-throughput, automated testing to discover, characterise and engineer novel proteins with potential across many therapeutic areas. We are seeking a Senior Director, Project & Alliance Management to drive cross-functional execution of programs from preclinical development through IND/CTA submission, first-in-human studies, and early clinical development, while ensuring effective governance of strategic partnerships. ## Key Responsibilities ### Project & Program Management (Preclinical through Clinical) - Lead cross-functional project management for programs from discovery and preclinical through IND-enabling work and into the clinic, owning integrated timelines, deliverables, risks and resource needs. - Demonstrated experience leading cross-functional development programs through IND/CTA-enabling activities, regulatory submission, and transition into clinical development. - Build and maintain development plans, milestones, decision points and risk registers with scientific, translational, CMC, regulatory, clinical and operations leaders; track dependencies across discovery, platform, development and alliance activities. - Run program team meetings and stage-gate reviews so decisions are documented and actions are owned; coordinate CRO/CDMO planning and oversight with functional owners. - Anticipate development challenges, evaluate tradeoffs, and drive timely cross-functional decisions to maintain program momentum. - Give executive leadership candid, consistent visibility into status, critical path and tradeoffs. ### Alliance Management - Serve as primary operational lead for strategic partnerships, aligning on objectives, responsibilities, milestones, decision rights and governance. - Lead Joint Steering Committees and other alliance forums: agendas, briefing materials, decision tracking and follow-through. - Translate collaboration agreements into operating plans; track obligations, deliverables, milestone and option events, and amendments. - Monitor alliance health, risks and dependencies, escalating with a recommended path forward; give operational input to negotiations with legal, finance and business development. - Manage alliance information flow, including data sharing and reporting obligations, and build trusted partner relationships. ### Resource, Time & Portfolio Tracking - Implement and own time tracking for project teams, giving a consistent view of effort by program, workstream, alliance and activity, while keeping it simple and low-burden for scientists. - Use the data for resource planning, capacity forecasting, FTE and budget reconciliation, portfolio prioritization and, where agreements require, alliance cost-sharing and reporting with finance. - Maintain portfolio dashboards covering timelines, milestones, resourcing and risk across all programs and alliances. ### Strategic Leadership - Partner with executives on portfolio prioritization, program sequencing, alliance strategy and resource allocation. - Build scalable governance frameworks, tools and reporting processes; drive continuous improvement and accountability internally and with partners. - Represent the function in internal planning and external partner forums; as the team grows, hire and develop talent. ## Required Qualifications - PhD, MS or MBA in life sciences or a related field, with 5+ years working closely with scientific teams in biotech or pharma. - 10–15+ years in biotech or pharma project/program, alliance or portfolio management, or related operational leadership. - Hands-on cross-functional project leadership across both preclinical and clinical development, ideally taking a program through IND/CTA into the clinic. - Demonstrated success managing complex external partnerships, including joint governance (JSC/JPT), contractual obligations and multi-stakeholder relationships. - Strong grasp of drug development, scientific operations and alliance execution in biotech. - Proficiency with planning tools (e.g., Smartsheet) and experience with time/effort tracking and resource management. - Proven ability to influence without authority, resolve conflict and drive accountability across matrixed teams. - Excellent communication and facilitation skills; thrives in a lean, entrepreneurial environment with shifting priorities. ## Preferred Qualifications - Programs spanning preclinical and clinical development, including Phase 1/2 execution. - Alliances involving scientific, legal, finance and executive stakeholders, including alliance financials and milestone tracking. - Building governance frameworks, program tools and reporting processes in a growing biotech. - Novel modalities or platform-enabled programs (e.g., biologics, protein therapeutics, computationally driven discovery). - Structured decision-making and executive governance in an early-stage biotech; PMP/PgMP or alliance management certification a plus. The salary range for this role is $213,000 - $280,500. For more fresh new jobs, check out [yubhub.co](https://yubhub.co/). ## Skills ### Required - life sciences - biotech - pharma - project management - alliance management - Smartsheet ### Nice to have - Phase 1/2 execution - alliance financials - milestone tracking - governance frameworks - program tools - reporting processes - novel modalities - platform-enabled programs - PMP/PgMP - alliance management certification --- Source: [Apply at job-boards.greenhouse.io](https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8941051002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)