# Senior Scientist I, Antibody Engineering

**Company**: Bighatbiosciences
**Location**: San Mateo, CA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full time
**Salary**: $160,000 - $185,000
**Category**: Lab Science
**Industry**: Healthcare

**Apply**: https://bighatbiosciences.pinpointhq.com/en/postings/f237fe02-5f68-47bc-8403-ba6502fd88f6?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_793d20ac-467

## Description

BigHat Biosciences is seeking a Senior Scientist I to lead therapeutic programs on the antibody engineering & binder generation team. You will drive antibody discovery, design, optimization, and characterization.

## Key Responsibilities

- Lead cross-functional project teams on the execution of rapid, iterative multi-objective optimization to identify high-value therapeutic antibodies.

- Understand target biology to better design antibodies that meet the company's candidate profile.

- Contribute expertise in antibody engineering approaches to generate and optimize novel antibodies.

- Collaborate with BigHat leadership and cross-functional team members to ensure a tight linkage between strategy, research, and development components.

- Lead in-depth data analysis of each design cycle to better leverage experimental and computational approaches.

- Communicate results to key decision makers, the broader BigHat team, and external partners.

## Skills, Knowledge & Expertise

- Ph.D. in biochemistry, structural biology, protein engineering, or related fields.

- 5+ years of advanced research experience in an industry setting.

- Hands-on protein engineering expertise, including structure-guided design, affinity maturation, and rational or computational approaches.

- Experience working with diverse antibody formats.

- Expertise in mammalian cell culture, immunoassay, molecular techniques, and protein expression and characterization.

- Exceptional written, verbal, and visual communication skills.

- Scientific track record and publication record.

- Strong data analysis and interpretation skills.

## Benefits

The salary estimated for this position is $160,000 - $185,000 + bonus + options + benefits.

## Skills

### Required
- biochemistry
- structural biology
- protein engineering
- antibody engineering
- mammalian cell culture
- immunoassay
- molecular techniques
- protein expression and characterization

### Nice to have
- agentic software tools

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Source: [Apply at bighatbiosciences.pinpointhq.com](https://bighatbiosciences.pinpointhq.com/en/postings/f237fe02-5f68-47bc-8403-ba6502fd88f6?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)