# Manager, LNP R&D **Company**: GenScript Biotech Corporation **Location**: Seattle, Washington **Work arrangement**: onsite **Experience**: senior **Job type**: full-time **Salary**: $125,000 – $160,000 **Category**: Research **Industry**: Healthcare **Apply**: https://job-boards.greenhouse.io/genscript/jobs/5293025007?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply **Canonical**: https://yubhub.co/job/manager-lnp-r-and-d-66723336-032/ ## Description GenScript is seeking a highly motivated and experienced scientific leader to lead its Lipid Nanoparticle (LNP) R&D team in Seattle. The successful candidate will bring multidisciplinary expertise in lipid nanoparticles, nucleic acid delivery, formulation development, and RNA therapeutics, together with demonstrated scientific leadership and people-management capability. This role will lead the development and commercialization of innovative RNA and nucleic acid delivery technologies, with a focus on LNP platforms for mRNA, DNA, small RNAs, and other emerging nucleic acid modalities. **Key Responsibilities** **Scientific and Technology Leadership** - Lead the development of innovative LNP and nucleic acid delivery platforms for mRNA, DNA, small RNAs, and other therapeutic payloads across diverse research and therapeutic applications. - Drive next-generation LNP development, including novel ionizable lipid design and synthesis, formulation optimization, targeted LNPs, extrahepatic delivery, and tissue- or cell-specific delivery strategies. - Establish technology roadmaps and development strategies that create differentiated LNP capabilities, products, and services. - Partner with the RNA R&D team to develop integrated RNA and delivery solutions for vaccines, gene editing, protein replacement, cell engineering, and other emerging applications. - Provide scientific leadership for LNP formulation design, screening, characterization, optimization, and delivery-performance evaluation. - Monitor emerging technologies, scientific publications, competitive platforms, intellectual-property trends, and industry developments in nucleic acid delivery. **Team Leadership and Development** - Build, lead, and develop a high-performing LNP R&D team, with responsibility for workforce planning, hiring, resource allocation, budgeting, performance management, and employee development. - Foster a culture of scientific rigor, innovation, accountability, collaboration, transparency, inclusion, and continuous improvement. - Mentor scientists through regular one-on-one meetings, technical guidance, career-development discussions, and timely, constructive feedback. - Allocate resources effectively to achieve project milestones, platform-development objectives, and organizational priorities. **Cross-Functional and Project Leadership** - Serve as the primary technical and organizational leader for LNP R&D and partner with RNA R&D, Operations, Production, Quality, Marketing, Sales, and Program Management. - Define project scope, technical strategy, milestones, resource requirements, risks, and timelines for key R&D programs. - Monitor project and team performance and communicate progress, risks, scientific findings, and recommendations to senior leadership through project reviews and presentations. - Review and approve key R&D deliverables, including research reports, experimental protocols, SOPs, technical procedures, production records, presentations, and scientific publications. **Technology Transfer and Commercialization** - Lead the translation of new LNP technologies from early-stage R&D into robust, scalable, customer-facing products and services. - Provide technical leadership for formulation scale-up, process optimization, technology transfer, and implementation in Production and Operations. - Work with Production, Quality, and Operations to establish reproducible processes, critical process parameters, analytical requirements, and fit-for-purpose documentation. - Identify opportunities to improve platform performance, operational efficiency, scalability, reproducibility, profitability, and customer value. **Customer and Market Engagement** - Serve as a technical expert in customer discussions involving LNP formulation, nucleic acid delivery, troubleshooting, and customized development programs. - Partner with Commercial, Marketing, and Program Management to understand customer needs and translate them into new capabilities and service offerings. - Participate in scientific conferences, technical seminars, and customer engagements to identify emerging trends and unmet needs. - Translate market and customer insights into actionable R&D priorities and technology roadmaps. **Laboratory, Quality, and Safety** - Oversee the development, implementation, and continuous improvement of laboratory procedures and technical workflows. - Promote high standards of scientific documentation, experimental reproducibility, data integrity, and laboratory organization. - Ensure compliance with applicable laboratory-safety requirements and GenScript EHS policies, particularly for lipid chemistry, formulation development, and chemical handling. - Collaborate with EHS, Quality, and site leadership to maintain a safe and compliant laboratory environment. **Required Qualifications** - PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering, Bioengineering, or a related discipline. - At least 5 years of relevant post-PhD industry or research experience in nucleic acid delivery, drug delivery, lipid nanoparticles, or related technologies. - At least 2 years of direct people-management experience leading scientific or technical teams, including hiring, coaching, performance management, employee development, and resource planning. - Deep scientific expertise in lipid nanoparticle formulation and nucleic acid delivery, particularly RNA delivery. - Demonstrated hands-on experience in LNP formulation, production, optimization, and analytical characterization. - Strong understanding of lipid-based and/or polymeric nucleic acid delivery technologies. - Experience with particle size/PDI, zeta potential, encapsulation efficiency, RNA concentration, lipid composition, morphology, and stability assessment. - Experience evaluating nucleic acid delivery performance in relevant in vitro and/or in vivo models. - Strong understanding of RNA biology and analytical methods for evaluating RNA quality, delivery, and functional expression. - Experience with relevant molecular and cellular methods, which may include RT-qPCR, ELISA, Western blotting, flow cytometry, fluorescence-based assays, gel electrophoresis, capillary electrophoresis, and RNA-quantification methods. - Demonstrated ability to analyze complex data, identify root causes, design effective experiments, and make data-driven development decisions. - Strong project-management and organizational capabilities, with the ability to manage multiple priorities and development programs. - Excellent scientific writing, presentation, interpersonal, and stakeholder-management skills. - Ability to collaborate effectively and influence across technical and business functions without direct authority. - High standards of integrity, scientific rigor, accountability, teamwork, and professional conduct. **Perks:** - Free colleague meals during shift - Onsite gyms **Compensation:** - Salary range: $125,000 – $160,000 total compensation, including bonus, depending on experience and qualifications. **Benefits:** - Benefits include medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. - Paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and company holidays. - Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. - Commuter benefits, well-being initiatives, and peer-to-peer recognition programs; For more fresh new jobs, check out [yubhub.co](https://yubhub.co/). ## Skills ### Required - Pharmaceutical Sciences - Chemistry - Biochemistry - Chemical Engineering - Biomedical Engineering - Bioengineering - Lipid Nanoparticle Formulation - Nucleic Acid Delivery - RNA Therapeutics - Project Management - Leadership - Team Management - Scientific Writing - Presentation - Interpersonal Skills - Stakeholder Management - Data Analysis - Experimental Design - RNA Biology - Analytical Methods - Molecular and Cellular Methods ### Nice to have - Novel Ionizable Lipid Design - Targeted LNPs - Extrahepatic Delivery - Cell-Specific Nucleic Acid Delivery - mRNA Therapeutics - Vaccines - Gene Editing - In Vivo Cell Engineering - siRNA - Technology Transfer - Scale-Up - Commercial Service Launch - CRO/CDMO - Biotechnology - Pharmaceutical - Life-Science Service Organization --- Source: [Apply at job-boards.greenhouse.io](https://job-boards.greenhouse.io/genscript/jobs/5293025007?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)