# Senior Research Associate, Viral Production (Fixed-Term Contract)

**Company**: Arc Institute
**Location**: Palo Alto, CA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: contract
**Salary**: $84,250 to $106,000
**Category**: Research
**Industry**: Technology

**Apply**: https://job-boards.greenhouse.io/arcinstitute/jobs/6221655004?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_6437738d-6eb

## Description

Arc Institute is seeking a highly skilled Senior Research Associate, Viral Production to join the Molecular Engineering team within the Genome Engineering Technology Center. This 18-month fixed-term position involves serving as a dedicated producer of lentivirus, supplying high-quality viral preps that power perturbation screening and cell engineering efforts across Arc's wet lab Tech Centers.

Responsibilities:

- Execute staggered rounds of lentivirus production using suspension and/or adherent systems.

- Concentrate, filter, and aliquot virus into single-use aliquots, and perform quality control on each lot.

- Help coordinate cross-functionally to forecast demand in advance, scaling and scheduling each round of production accordingly.

- Maintain rigorous, organized documentation of production runs, titer/QC outcomes, and viral inventory and distribution.

- Perform troubleshooting on failed productions, escalate and reschedule as needed.

- Maintain inventory of key reagents, media, and consumables to ensure uninterrupted production.

- Help establish, refine, and run an efficient end-to-end viral production platform.

- Contribute to process optimization aimed at improving the scale, quality, and lot-to-lot consistency of production.

Requirements:

- BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience.

- Proficiency in mammalian cell culture procedures and associated aseptic techniques.

- Direct hands-on experience producing lentivirus at scale using suspension and/or adherent systems.

- Demonstrated ability to execute reproducible, multi-step production protocols consistently across repeated rounds.

- Experience with viral titration and QC methods.

- Experience with filtering, single-use aliquoting, cryopreservation, and inventory management of viral stocks.

- Meticulous documentation and record-keeping; comfort working to a production schedule.

- Excellent communication skills and the ability to coordinate effectively across teams.

Preferred Qualifications:

- Experience developing or leveraging automation for viral production and/or titration at scale.

- Prior experience independently optimizing processes and workflows to improve viral yield, quality, and consistency.

- Hands-on experience with multiple viral production systems and protocols.

- Experience producing lentivirus in arrayed formats as well as large-scale pooled-library formats.

- Experience managing external vendor relationships for cloning and plasmid preps.

The base salary range for this position is $84,250 to $106,000.

## Skills

### Required
- lentivirus production
- mammalian cell culture
- viral titration
- QC methods
- documentation
- communication

### Nice to have
- automation
- process optimization
- multiple viral production systems
- vendor relationships

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