# Principal Scientist, Structural Biology / Protein Biophysics

**Company**: Flagship Labs 132 (FL132)
**Location**: Cambridge, MA
**Experience**: senior
**Job type**: full-time
**Salary**: $163,000 - $214,500
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8928133002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
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## Description

We are seeking a motivated, highly collaborative, and technically versatile Principal Scientist to help build FL132’s amyloid research platform from the ground up. This is a hands-on role at the interface of protein biophysics, chemical biology, structural biology, and neurodegeneration.

Key Responsibilities:

- Contribute to scientific and technical direction in collaboration with FSP leadership to shape company strategy.

- Establish in-house production and quality control of assay-grade recombinant amyloid proteins.

- Design and analyze amyloid aggregation experiments.

- Characterize amyloid aggregates via mass spectrometry, NMR, AFM, or related methods.

- Support the build of cell-based assays for evaluating amyloid toxicity, seeding, and clearance.

- Evaluate inhibitors of amyloid aggregation and translate findings from biochemical systems into cellular models.

- Scope, contract, and manage CROs and academic collaborations.

- Drive key project goals, ensure rapid, accurate turnaround of data and translate experimental results into insights.

Required Qualifications:

- Ph.D. in structural biology, chemical biology, biochemistry, biophysics, physical chemistry, or a related field, with 8+ years of relevant industry or postdoctoral experience.

- Hands-on recombinant protein expression, purification, and QC.

- Deep expertise with kinetic assays of protein aggregation.

- Familiarity with amyloid aggregation mechanisms and strain/seeding biology.

- Motivated team-player and effective independent contributor with strong organizational and written/verbal communication skills.

Preferred Qualifications:

- Experience with structural characterization of proteins and aggregates using mass spectrometry-based approaches.

- Familiarity with cryo-EM, atomic force microscopy (AFM) or NMR.

- Experience with statistical design of experiments (DoE) and the analysis of large, time-resolved kinetic datasets.

- Experience managing contract research organizations (CROs).

- Familiarity with cell-based neurodegeneration assays.

What we can offer you:

- Opportunity to lay the scientific foundation of a transformative platform company as an early employee.

- Custom-tailored role to maximize impactful contributions, professional growth, and scientific interests.

- Monthly social events, and community lunchroom with free snacks, coffee.

## Skills

### Required
- structural biology
- chemical biology
- biochemistry
- biophysics
- protein expression
- purification
- QC
- kinetic assays
- protein aggregation
- amyloid aggregation mechanisms

### Nice to have
- mass spectrometry
- cryo-EM
- atomic force microscopy
- NMR
- statistical design of experiments
- contract research organizations
- cell-based neurodegeneration assays

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