# Senior Scientist, Developability [Contract]

**Company**: Bighatbiosciences
**Location**: San Mateo, CA
**Work arrangement**: onsite
**Experience**: senior
**Job type**: contract temp
**Category**: Lab Science
**Industry**: Healthcare

**Apply**: https://bighatbiosciences.pinpointhq.com/en/postings/a785ab55-3527-4a69-a39c-1c4e7db4b8d9?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_525e39ee-564

## Description

BigHat Biosciences is seeking a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late-stage drug candidates from its Milliner Platform for AI-designed therapeutics.

This is a lab-based 12-month contract role, with the possibility but no guarantee of conversion to a full-time position. You will spend most of your time at the bench executing complex stability studies.

## Key Responsibilities

- Design, lead, and execute in-use dose solution studies to assess drug compatibility with administration materials.

- Develop highly sensitive protein characterization methods, such as qSEC, RP-HPLC, CEX, and particle counting, to evaluate drug quality and recovery.

- Support late-stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates.

- Drive developability assessments, focusing on purity, stability, tolerability, and biophysical properties across programs, with careful attention to data interpretation and organisation.

- Manage and communicate with external CROs for testing and analytics.

- Interpret and communicate scientific findings, propose next steps, and effectively broadcast results across the organisation.

- Proactively identify and explore state-of-the-art analytical tools and developability technologies.

## Skills, Knowledge & Expertise

- PhD in Biochemistry or a relevant discipline with 5+ years of industry experience; exceptional non-PhD candidates with extensive bench experience will be considered.

- Experience in developing and optimising sensitive analytical chromatography-based methods is essential.

- Strong background in biophysical and analytical characterisation of antibodies and antibody fragments, including SEC, HIC, CE-SDS, DLS, DSF, ELISA, and LC-MS.

- Proven track record of translating complex data into clear results and actionable recommendations.

- Keenness to learn and onboard new technologies to enhance capabilities, improve work quality, timelines, throughput, or cost.

## Skills

### Required
- Biochemistry
- Analytical chromatography
- Biophysical characterisation
- Antibody fragments
- SEC
- HIC
- CE-SDS
- DLS
- DSF
- ELISA
- LC-MS

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Source: [Apply at bighatbiosciences.pinpointhq.com](https://bighatbiosciences.pinpointhq.com/en/postings/a785ab55-3527-4a69-a39c-1c4e7db4b8d9?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)