# Principal Scientist, Oncology Drug Discovery

**Company**: GSK
**Location**: Cambridge
**Work arrangement**: onsite
**Experience**: senior
**Job type**: full-time
**Salary**: $115,500 to $192,500
**Category**: Research
**Industry**: Healthcare

**Apply**: https://gsk.wd5.myworkdayjobs.com/en-US/GSKCareers/job/Cambridge-300-Technology-Square/Principal-Scientist--Oncology-Drug-Discovery_450693?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
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## Description

We are seeking an experienced Cancer Biologist for an Investigator role to support a growing portfolio of precision oncology assets.

The successful candidate will have a background in cancer biology with experience designing and executing biological studies to understand the mechanism of action small molecule cancer therapeutics.

Responsibilities:

- Work within a dynamic and global matrix team environment providing basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.

- Work independently to design, execute, and/or oversee impactful in vitro experiments to inform the development of portfolio assets.

- Champion innovative experimental techniques or technologies, including medium-throughput scalable assay development, target-specific mechanistic biology, and monotherapy and combination anti-cancer efficacy testing of assets.

- Build communication networks across the Oncology Research Unit and broader organization.

- Guide the maturation and de-risking of novel therapeutic concepts.

Basic Qualifications:

- BS, MS, or PhD in Cell, Molecular, or Cancer Biology, Pharmacology, or a related life sciences field.

- A minimum of 3 years of experience in designing, executing, and analyzing cellular and molecular biology experiments using small molecular therapeutics and a diverse array of current scientific techniques.

Preferred Qualifications:

- A minimum of 2 years of drug discovery experience in a biotech, preclinical CRO or pharmaceutical company.

- Deep knowledge in the field of molecular oncogenesis, signaling pathway, bivalent or molecular glue modality.

- Deep expertise in assay development in a drug discovery setting.

- Experience in applying genomic editing techniques to dissect target biology and drug mechanisms.

- Proven track record of scientific expertise and achievement in cell biology and cancer biology through peer-reviewed publications.

- Working knowledge of omic methods and databases.

Benefits:

- Competitive salary

- Annual bonus based on company performance

- Healthcare and wellbeing programs

- Pension plan membership

- Shares and savings programme

- Performance with Choice programme offering remote or hybrid working model

## Skills

### Required
- Biological Pathways
- Cancer Research
- Cross-Functional Teamwork
- Drug Discovery Process
- Drug Target Identification
- Influencing Without Authority
- Interpersonal Communication
- Matrix Leadership
- Proper Documentation
- Scientific Presentations
- Scientific Research
- Scientific Writing

### Nice to have
- Molecular Oncogenesis
- Signaling Pathway
- Bivalent or Molecular Glue Modality
- Assay Development
- Genomic Editing Techniques
- Omic Methods
- Databases

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