# Senior Scientist, Discovery Science **Company**: FL125 **Location**: Cambridge, MA **Experience**: senior **Job type**: full-time **Salary**: $126,000 - $181,500 **Category**: Research **Industry**: Healthcare **Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8937270002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply **Canonical**: https://yubhub.co/job/senior-scientist-discovery-science-41497e03-ed5/ ## Description What if… you could join an organisation that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? FL125 is a cutting-edge biotechnology platform company developing oligonucleotide therapies enabling superior solutions for therapeutic, diagnostics and tool development. This is a unique opportunity to be one of the first employees of a biotech startup that combines an innovative, and disruptive mindset with the resources and know-how of Flagship Pioneering. We are seeking a motivated and highly collaborative Senior Scientist to join our Discovery Biology team. The successful candidate will bring a deep understanding of biochemistry, assay development, and tissue sample processing, with a strong track record of collaborating with in-vivo pharmacologists / in-vivo biologists, NGS scientists, and bioinformatics teams. The role also involves management of contract research organisations (CROs). Key Responsibilities: - Drive translational platform innovation aligned with FL125’s core strategic goals, with a focus on biochemical assay development, analysis of oligonucleotides in complex mixtures, and tissue processing. - Generate and develop enhanced oligonucleotides in different biological settings and against a broad set of drug targets. - Support the design of in vivo experiments based on protocols developed in-vitro. - Work in close collaboration with biochemists, in-vivo biologists, NGS scientists, and bioinformatics teams. - Work closely with CROs conducting in-vitro / in-vivo experiments to identify new drug molecules. - Generate rapid and accurate turnaround of high-quality experimental data to drive decision-making for platform and pipeline programs. - Establish and refine workflows, SOPs, and documentation practices for experimental processes at scale. - Clearly communicate experimental design, results, challenges, and next steps in internal meetings and with external collaborators. Qualifications: - PhD in molecular biology, biochemistry, drug discovery, or a related field, with 3+ years of industry experience in discovery research. Postdoctoral experience may also be acceptable depending on research focus. - Hands-on experience designing and interpreting complex in vitro and ex vivo experimental workflows, including sample processing and assay development. - Good understanding of in vivo experiments for drug discovery and development in mouse models. - Some familiarity with high-dimensional readouts such as NGS and proteomics. - Hands-on experience with standard biochemical techniques and an ability to troubleshoot and optimize complex experimental workflows. - Track record of working in multidisciplinary teams, including biochemists, in vivo biologists, and bioinformaticians. - Motivated team-player and independent force-of-nature with strong organisational and written/verbal communication skills. Preferred Qualifications: - Experience working with oligonucleotides. - Experience designing and executing mouse model experiments. - Experience working with contract research organisations (CROs). What we can offer you: - Opportunity to lay the scientific foundation of a transformative platform company as an early employee. - A custom-tailored role to maximize impactful contributions, professional growth, and scientific interests. - Tightly knit team, social activities and community lunchroom with free snacks, and a vibrant community of scientists and entrepreneurs. For more fresh new jobs, check out [yubhub.co](https://yubhub.co/). ## Skills ### Required - biochemistry - assay development - tissue sample processing - in-vivo pharmacology - NGS - bioinformatics ### Nice to have - oligonucleotides - mouse model experiments - contract research organisations --- Source: [Apply at job-boards.greenhouse.io](https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8937270002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)