# Director, Cardiovascular and metabolic diseases, Clinical Pharmacology Modeling and Simulation

**Company**: GSK
**Location**: Massachusetts - Waltham
**Experience**: senior
**Job type**: full-time
**Salary**: $188,100 to $313,500
**Category**: Healthcare
**Industry**: Healthcare

**Apply**: https://gsk.wd5.myworkdayjobs.com/en-US/GSKCareers/job/USA---Massachusetts---Waltham/Director--Cardiovascular-and-metabolic-diseases--Clinical-Pharmacology-Modeling-and-Simulation_450639-1?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_34a6efaf-85d

## Description

The Department of Clinical Pharmacology Modelling & Simulation in Respiratory and Inflammation (CPMS R&I) at GSK is recruiting for a Director–level Clinical Pharmacologist with cardiovascular and metabolic disease expertise.

This role sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation, which aims to be a centre of excellence in Model‑Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling.

You will lead the end‑to‑end application of MIDD across the drug development lifecycle - from first‑in‑human studies through filing and lifecycle management - and provide clinical pharmacology strategy and evidence‑generation input.

Main responsibilities and accountabilities include:

- Design & Execute Model Informed and Clinical Pharmacology strategies

Develop and implement robust MIDD & ClinPharm evidence strategies to de risk and accelerate RIIRU programs.

- Ensure robust ways of working and regulatory ready evidence

Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling.

- Build cross functional partnerships

Work closely with CPQM peers and cross functional partners.

- External engagement & scientific leadership

Raise GSK’s profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora.

**Basic Qualifications:**

- PhD, MD, or PharmD

- 5+ years of industry experience in clinical pharmacology, modelling/simulation and drug development.

- Experience in pharmacometrics and its application to clinical questions in drug development.

**Preferred Qualifications:**

- Experience in Cardiovascular and metabolic diseases.

- Demonstrated experience of collaboration in a multi-disciplinary team.

- Evidenced experience making sound judgement in complex situations.

- Experience working with senior stakeholders in a cross functional environment.

- Track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches.

**Skills** Drug Design, Drug Development, Drug Discovery Process, Drug Discovery Research, Medication Safety, Molecular Modeling, Pharmaceutical Regulatory Compliance, Pharmaceutical Sciences, Pharmacodynamics, Pharmacokinetics, Pharmacology, Pharmacometrics, Pharmacovigilance, Study Design, Target Validation

## Skills

### Required
- PhD
- MD
- PharmD
- clinical pharmacology
- modelling/simulation
- drug development
- pharmacometrics

### Nice to have
- Cardiovascular and metabolic diseases
- collaboration
- judgement
- senior stakeholders
- MIDD approaches

---

Source: [Apply at gsk.wd5.myworkdayjobs.com](https://gsk.wd5.myworkdayjobs.com/en-US/GSKCareers/job/USA---Massachusetts---Waltham/Director--Cardiovascular-and-metabolic-diseases--Clinical-Pharmacology-Modeling-and-Simulation_450639-1?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)