# Principal Statistical Programmer

**Company**: IQVIA
**Location**: Durham, North Carolina
**Experience**: senior
**Job type**: full-time
**Salary**: $98,200.00 - $273,200.00
**Category**: Data Science
**Industry**: Healthcare

**Apply**: https://iqvia.wd1.myworkdayjobs.com/en-US/IQVIA/job/Durham-North-Carolina-United-States-of-America/Principal-Statistical-Programmer_R1577809?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/job/principal-statistical-programmer-25436b08-af8/

## Description

We are seeking a Principal Statistical Programmer to provide full end-to-end statistical programming support across clinical development programs.

This role requires deep technical expertise, leadership, and hands-on delivery, covering SDTM, ADaM, TLF development, and regulatory submission support.

**Key Responsibilities**

- Provide end-to-end statistical programming support for clinical studies from study setup through submission

- Lead and perform development and validation of SDTM datasets, ADaM datasets, and Tables, Listings, and Figures (TLFs)

- Ensure all deliverables are compliant with CDISC standards and regulatory requirements

- Support regulatory submissions, including define.xml, submission-ready datasets, and reviewer’s guides

- Serve as a Principal-level programmer, providing technical leadership and guidance to other programmers as needed

- Contribute to and help maintain programming standards, macros, and validation processes

- Review and approve programming deliverables to ensure accuracy, consistency, and quality

- Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams

- Proactively identify risks and propose efficient, compliant solutions within timelines

**Required Qualifications**

- Bachelor’s or Master’s degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field

- Extensive experience as a statistical programmer, with demonstrated Principal-level responsibilities

- Strong hands-on experience with SDTM and ADaM dataset development, TLF programming, and regulatory submission deliverables

- Expert proficiency in base SAS and Advanced SAS with good hands-on SAS Macros

- In-depth knowledge of CDISC standards, regulatory guidelines, and submission requirements

- Proven ability to manage complex studies independently from start to finish

The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00.

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## Skills

### Required
- SDTM
- ADaM
- TLF programming
- CDISC standards
- base SAS
- Advanced SAS
- SAS Macros

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Source: [Apply at iqvia.wd1.myworkdayjobs.com](https://iqvia.wd1.myworkdayjobs.com/en-US/IQVIA/job/Durham-North-Carolina-United-States-of-America/Principal-Statistical-Programmer_R1577809?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)