# Senior Scientist (R4) **Company**: Pfizer **Location**: Bothell, Washington **Work arrangement**: onsite **Experience**: senior **Job type**: full-time **Salary**: $93,600.00 to $156,000.00 **Category**: Research **Industry**: Healthcare **Apply**: https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Washington--Bothell/Senior-Scientist--Downstream-Process-Development-R-D_4966126?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply **Canonical**: https://yubhub.co/jobs/job_0c9c5494-c3a ## Description A Senior Scientist (R4) position is available in the Downstream Process Development group within Bioprocess R&D at Pfizer in Bothell, Washington. The successful candidate will have strong laboratory research experience and a desire to remain in a hands-on, laboratory-focused role. This position will be part of a multidisciplinary team of scientists across multiple sites focused on the development and optimization of recovery and purification processes for recombinant proteins expressed in mammalian cell culture, supporting early- and late-phase clinical programs. The Senior Scientist will work collaboratively to develop robust, efficient, and scalable downstream strategies to improve process performance and enable successful technology transfer. **Role Responsibilities** - Design and execute small-scale downstream process development studies, with support for pilot-scale and manufacturing purification activities. - Analyze experimental data to develop, test, and refine hypotheses that improve the fundamental understanding of recovery and purification processes. - Contribute to process characterization, validation strategies, Quality by Design (QbD) approaches, and regulatory filings. - Author internally reviewed technical reports, present scientific results to cross-functional teams and management, and publish externally as appropriate. - Identify and implement opportunities for operational efficiency and continuous improvement across Bioprocess R&D workflows. - Support change initiatives related to business infrastructure, platforms, and technologies to enable pipeline, legacy, and innovation programs. **Basic Qualifications** - Bachelor’s degree with 8+ years of relevant experience, or Master’s degree with 6+ years of relevant experience, or PhD with 0–3 years of experience - Degrees should be in a biological or engineering discipline (e.g., Biotechnology, Chemistry/Biochemistry, Chemical or Biochemical Engineering, or equivalent). **Experience/Skills** - Hands-on experience in recombinant protein downstream process development, technology transfer, and/or bioprocess manufacturing. - Strong understanding of protein chemistry and protein analytics, with demonstrated ability to apply current scientific literature. - Proven ability to independently drive experimental work, deliver results, and contribute innovative solutions within project teams. - Highly organized, self-motivated, and capable of working both independently and collaboratively in a matrix environment. - Excellent written and verbal communication skills, including technical documentation and presentations. - Strong analytical, data interpretation, and computer skills. - Ability to manage personal workload effectively and contribute to planning of people and technology resources within project teams. - Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem-solving and enhance productivity. - Demonstrated curiosity for exploring how these tools can improve outcomes and understanding of responsible AI practices, including risk management and ethical use. **Preferred Qualifications** - Experience with recovery and purification of recombinant proteins from mammalian and microbial or yeast expression systems. - Experience transferring biologics processes to pilot-scale or commercial manufacturing, including familiarity with data acquisition and process control systems. - Experience supporting late-stage development, process validation, and commercialization activities. - Working knowledge of statistical experimental design and data analysis. - Broad understanding of the biologics drug development process and requirements for advancing candidates through clinical development. **Benefits** - Comprehensive and generous benefits and programs to help colleagues lead healthy lives and support each of life's moments. - 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution. - Paid vacation, holiday, and personal days. - Paid caregiver/parental and medical leave. - Health benefits, including medical, prescription drug, dental, and vision coverage. **Salary** - The annual base salary for this position ranges from $93,600.00 to $156,000.00. - Eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary. - Eligible to participate in our share-based long-term incentive program. ## Skills ### Required - Biotechnology - Chemistry/Biochemistry - Chemical or Biochemical Engineering - protein chemistry - protein analytics - experimental design - data analysis - AI tools - generative technologies - ChatGPT - Microsoft Copilot ### Nice to have - recovery and purification of recombinant proteins - mammalian and microbial or yeast expression systems - biologics process transfer - pilot-scale or commercial manufacturing - statistical experimental design - biologics drug development process --- Source: [Apply at pfizer.wd1.myworkdayjobs.com](https://pfizer.wd1.myworkdayjobs.com/en-US/PfizerCareers/job/United-States---Washington--Bothell/Senior-Scientist--Downstream-Process-Development-R-D_4966126?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply)