# Principal / Senior Principal Scientist, DMPK

**Company**: Alltrna
**Location**: Cambridge, MA
**Experience**: senior
**Job type**: full-time
**Salary**: $179,000 - $236,000
**Category**: Research
**Industry**: Healthcare

**Apply**: https://job-boards.greenhouse.io/flagshippioneeringinc/jobs/8621271002?utm_source=yubhub.co&utm_medium=jobs_feed&utm_campaign=apply
**Canonical**: https://yubhub.co/jobs/job_0a1636be-d82

## Description

Reporting to the Chief Scientific Officer, this role leads DMPK strategy and oversees bioanalytical work across nonclinical and clinical programs, operating as a hands-on scientific leader.

We are looking for an accomplished DMPK scientist with experience in PK and PK-PD study design, PK data analysis and interpretation, and translational biomarker strategy.

Responsibilities:

- Lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts

- Oversee development, qualification, and validation of nonclinical and clinical bioanalytical assays, as well as sample analysis, working with internal and CRO analytical scientists

- Design, execute, and oversee PK and PK-PD studies of tRNAs to evaluate delivery technologies, biodistribution, and biomarker effects

- Lead PK and PK-PD data analysis and interpretation across mouse, rat, NHP, and human studies to support dose selection

- Manage and qualify CRO and external lab partners across bioanalytical and PK programs

- Support nonclinical toxicology programs in collaboration with internal teams and CROs

- Analyze, interpret, and present DMPK and translational biomarker data to internal leadership and external stakeholders

- Author nonclinical sections of regulatory filings and briefing documents; support agency interactions and responses

- Serve on the Research Leadership Team; represent DMPK and bioanalytical sciences in cross-functional program discussions

- Manage and develop direct report(s); collaborate with the broader pharmacology team

Required Qualifications:

- PhD or equivalent in pharmacokinetics, pharmacology, biochemistry, or related field

- 8+ years of industry experience in DMPK or a closely related function

- Working knowledge of bioanalytical methods, such as LC-MS/MS, ligand binding assays, and NGS

- Demonstrated CRO oversight, including vendor qualification, study monitoring, and data review

- Experience designing and overseeing in vivo nonclinical PK and PK-PD studies for novel delivery modalities; LNP experience preferred

- Hands-on experience with PK and PK-PD data analysis and associated software, such as Phoenix WinNonlin

- Experience in translational or clinical biomarker development, including assay strategy and fit-for-purpose qualification

- Strong scientific writing skills, including regulatory documents and internal study reports

- Experience supervising and developing scientists

Preferred Qualifications:

- Experience in rare disease or genetic medicine

- Experience with RNA-based therapies

- Familiarity with LNP platform biology and delivery landscape

- Familiarity with GLP toxicology study design and ICH nonclinical guidelines

- Experience operating in a cross-functional leadership role at a clinical-stage biotech

- Experience with ligand binding assays and multiplex immunoassay platforms for cytokine, immunogenicity, and biomarker analysis

## Skills

### Required
- PK and PK-PD study design
- bioanalytical methods
- CRO oversight
- data analysis and interpretation
- translational biomarker development
- scientific writing
- leadership and management

### Nice to have
- rare disease or genetic medicine
- RNA-based therapies
- LNP platform biology
- GLP toxicology study design
- cross-functional leadership
- ligand binding assays and multiplex immunoassay platforms

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