# Senior Director, LNP Formulation & Process Development

**Company**: Mirai Bio
**Location**: Cambridge, MA
**Experience**: senior
**Job type**: full-time
**Salary**: $213,000 - $280,500
**Category**: Research
**Industry**: Healthcare

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## Description

We are seeking an experienced Senior Director of Lipid Nanoparticle (LNP) Formulation & Process Development to lead the company's LNP formulation, process development, and small-scale production organization.

The Senior Director will provide scientific and operational leadership across multiple programs, establish LNP development and production strategies, and build scalable, reproducible capabilities to support a growing portfolio.

Key responsibilities:

- Lead the LNP formulation, process development, and small-scale production function supporting partner and internal programs.

- Establish technical strategy and best practices for LNP formulation, process development, characterization, and production across multiple payloads and applications.

- Provide senior technical leadership across multiple programs, including development strategy, experimental planning, data review, risk mitigation, and technical recommendations.

- Serve as a senior technical interface with clients and partners and support proposals, project scopes, presentations, and business development activities.

- Oversee non-GMP production of LNP formulations for in vitro, in vivo, and preclinical studies.

- Drive technical troubleshooting, process optimization, technology transfer, and continuous improvement of LNP production for mRNA, siRNA, gene-editing components, and other nucleic acid payloads.

- Establish workflows, documentation, and operational practices that improve quality, reproducibility, efficiency, and scalability.

- Lead, mentor, and develop the LNP team while managing priorities, resources, capacity, and organizational growth.

- Collaborate cross-functionally to align LNP development and production with broader program and company objectives.

Professional experience and qualifications:

- Ph.D. in Pharmaceutical Sciences, Chemical Engineering, Bioengineering, Chemistry, Biochemistry, or related field with 12+ years of relevant industry experience; M.S. with 14+ years; or B.S. with 16+ years.

- Extensive hands-on experience in LNP formulation and process development.

- Deep understanding of LNP composition, formation, purification, characterization, and the relationships between process parameters and product attributes.

- Demonstrated ability to lead complex technical programs, interpret data, troubleshoot problems, and establish development strategies.

- Proven experience leading and developing scientific teams and managing multiple concurrent programs and resources.

- Strong written, verbal, presentation, and client-facing communication skills.

The salary range for this role is $213,000 - $280,500. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

## Skills

### Required
- LNP formulation
- process development
- Pharmaceutical Sciences
- Chemical Engineering
- Bioengineering
- Chemistry
- Biochemistry

### Nice to have
- CMO
- CDMO
- CRO
- technology transfer
- GMP manufacturing

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